Oscillations in Cyclical Neutropenia

George Vash, Alec Morley, Frederick Stohlman

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)


To the Editor: Drs. Morley and Stohlman (N.E.J.M. March 19, 1970) induced bone-marrow depression in dogs with cyclophosphamide (Cytoxan) and produced cyclic neutropenia, which they convincingly ascribed to a deficiency of stem cells. They apparently overlooked earlier observations (Brodsky, Reimann and Dennis, Amer J Med 38:802, 1965) that anticipate their conclusions: here, the downward phase of cyclic neutropenia in man was modified with testosterone injections, and the pyrogen stimulation test of Fink and Calabresi (Ann Intern Med 157:11, 1961) was used to assay marrow stem-cell activity. Marrow granulocytic reserve, found absent at the low phase of cyclic neutropenia, was restored ….

Original languageEnglish
Number of pages1
JournalNew England Journal of Medicine
Issue number21
Publication statusPublished - 21 May 1970
Externally publishedYes


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