TY - JOUR
T1 - Oscillations in Cyclical Neutropenia
AU - Vash, George
AU - Morley, Alec
AU - Stohlman, Frederick
PY - 1970/5/21
Y1 - 1970/5/21
N2 - To the Editor: Drs. Morley and Stohlman (N.E.J.M. March 19, 1970) induced bone-marrow depression in dogs with cyclophosphamide (Cytoxan) and produced cyclic neutropenia, which they convincingly ascribed to a deficiency of stem cells. They apparently overlooked earlier observations (Brodsky, Reimann and Dennis, Amer J Med 38:802, 1965) that anticipate their conclusions: here, the downward phase of cyclic neutropenia in man was modified with testosterone injections, and the pyrogen stimulation test of Fink and Calabresi (Ann Intern Med 157:11, 1961) was used to assay marrow stem-cell activity. Marrow granulocytic reserve, found absent at the low phase of cyclic neutropenia, was restored ….
AB - To the Editor: Drs. Morley and Stohlman (N.E.J.M. March 19, 1970) induced bone-marrow depression in dogs with cyclophosphamide (Cytoxan) and produced cyclic neutropenia, which they convincingly ascribed to a deficiency of stem cells. They apparently overlooked earlier observations (Brodsky, Reimann and Dennis, Amer J Med 38:802, 1965) that anticipate their conclusions: here, the downward phase of cyclic neutropenia in man was modified with testosterone injections, and the pyrogen stimulation test of Fink and Calabresi (Ann Intern Med 157:11, 1961) was used to assay marrow stem-cell activity. Marrow granulocytic reserve, found absent at the low phase of cyclic neutropenia, was restored ….
UR - http://www.scopus.com/inward/record.url?scp=0014957622&partnerID=8YFLogxK
U2 - 10.1056/NEJM197005212822124
DO - 10.1056/NEJM197005212822124
M3 - Letter
C2 - 5445888
AN - SCOPUS:0014957622
SN - 0028-4793
VL - 282
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -