It is important to understand the development of osteoarthritis to improve the medical approach to this disease. However, it is still not clear how this disease affects the mechanical behavior and structure of cancellous bone. The aim of this study was to compare osteoarthritic cancellous bone to non-pathologic bone in terms of mechanical behavior and structural parameters, using groups paired by bone volume fraction and patient age. Thirty-eight cancellous bone specimens (seventeen for each group) were extracted, analyzed in micro-CT and mechanically tested. The results of the two groups were compared using a Mann-Whitney test. Furthermore, for both groups a linear regression was plotted between ultimate stress and minimum bone volume fraction. No significant difference was found between the two groups in ultimate stress or any of the morphometric parameters, except for the second normalized eigenvalue. Furthermore, no significant difference in slope or intercept point was found between the regression lines of the two groups. These preliminary results seem to indicate that the trabecular structure of osteoarthritic bone compensates for the degeneration of its tissue by orientating itself in the direction of the main load.