Osteoarthritic cancellous bone seems to orientate its structure to compensate for tissue degeneration

Caroline Öhman, S. Tassani, E. Perilli, F. Baruffaldi, M. Baleani, M. Viceconti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is important to understand the development of osteoarthritis to improve the medical approach to this disease. However, it is still not clear how this disease affects the mechanical behavior and structure of cancellous bone. The aim of this study was to compare osteoarthritic cancellous bone to non-pathologic bone in terms of mechanical behavior and structural parameters, using groups paired by bone volume fraction and patient age. Thirty-eight cancellous bone specimens (seventeen for each group) were extracted, analyzed in micro-CT and mechanically tested. The results of the two groups were compared using a Mann-Whitney test. Furthermore, for both groups a linear regression was plotted between ultimate stress and minimum bone volume fraction. No significant difference was found between the two groups in ultimate stress or any of the morphometric parameters, except for the second normalized eigenvalue. Furthermore, no significant difference in slope or intercept point was found between the regression lines of the two groups. These preliminary results seem to indicate that the trabecular structure of osteoarthritic bone compensates for the degeneration of its tissue by orientating itself in the direction of the main load.

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering
Subtitle of host publicationImage Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
Pages1389-1391
Number of pages3
Edition4
DOIs
Publication statusPublished - 1 Dec 2009
Externally publishedYes
EventWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics - Munich, Germany
Duration: 7 Sep 200912 Sep 2009

Publication series

NameIFMBE Proceedings
Number4
Volume25
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics
CountryGermany
CityMunich
Period7/09/0912/09/09

Keywords

  • Cancellous bone
  • Mechanical testing
  • Morphometric parameters
  • Osteoarthritis
  • Strength

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    Öhman, C., Tassani, S., Perilli, E., Baruffaldi, F., Baleani, M., & Viceconti, M. (2009). Osteoarthritic cancellous bone seems to orientate its structure to compensate for tissue degeneration. In World Congress on Medical Physics and Biomedical Engineering: Image Processing, Biosignal Processing, Modelling and Simulation, Biomechanics (4 ed., pp. 1389-1391). (IFMBE Proceedings; Vol. 25, No. 4). https://doi.org/10.1007/978-3-642-03882-2-368