Osteoconduction of impacted porous titanium particles with a calcium-phosphate coating is comparable to osteoconduction of impacted allograft bone particles: in vivo study in a nonloaded goat model.

Lucas Walschot, René Aquarius, Berend Schreurs, Nico Verdonschot, Pieter Buma

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Aims: Impaction grafting restores bone defects in hip arthroplasty. Defects are reconstructed with bone particles (BoP) as substitute materials with adequate mechanical and biological properties are not yet available. Ceramic particles (CeP) have mechanical drawbacks as opposed to porous titanium particles (TiP). In this in vivo study, bone ingrowth and bone volume in coated and noncoated TiP were compared to porous biphasic calcium-phospate CeP and allograft BoP. Coatings consisted of silicated calcium-phosphate and carbonated apatite. Materials were implanted in goats and impacted in cylindrical defects (diameter 8 mm) in the cancellous bone of the femur. On the basis of fluorochrome labeling and histology, bone ingrowth distance was measured at 4, 8, and 12 weeks. Cross-sectional bone area was measured at 12 weeks. Findings: TiP created a coherent matrix of entangled particles. CeP pulverized and were noncoherent. Bone ingrowth in TiP improved significantly by the coatings to levels comparable to BoP and CeP. Cross-sectional bone area was smaller in CeP and TiP compared to BoP. Conclusions: The osteoconductive properties of impacted TiP with a calcium-phosphate coating are comparable to impacted allograft bone and impacted biphasic ceramics. A more realistic loaded in vivo study should prove that coated TiP is an attractive alternative to allograft bone.

    Original languageEnglish
    Pages (from-to)1483-1489
    Number of pages7
    JournalJournal of Biomedical Materials Research Part B: Applied Biomaterials
    Volume100B
    Issue number6
    DOIs
    Publication statusPublished - Aug 2012

    Keywords

    • arthroplasty
    • bone ingrowth
    • porous
    • tissue engineering
    • titanium

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