Abstract
Introduction: This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) of the oesophagus.
Methods: The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty‐two (52%) were female. Survival data were available for all patients. The log rank test was performed to identify prognostic factors for survival.
Results: The 5‐year overall survival rate was 33% (median: 24 months). Of 61 patients, 42 (69%) received neoadjuvant therapy prior to surgery. The overall resection rate was 95%. Significant post‐operative morbidity occurred in 47%, and the in‐hospital mortality was 5% (30‐day mortality: 3%). No overall survival benefit was seen in patients undergoing neoadjuvant therapy prior to surgical resection. However, patients who had a complete pathological response to neoadjuvant therapy had a better 5‐year survival than patients who did not receive neoadjuvant therapy: 47% versus 30%, respectively.
Conclusions: Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome.
Methods: The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty‐two (52%) were female. Survival data were available for all patients. The log rank test was performed to identify prognostic factors for survival.
Results: The 5‐year overall survival rate was 33% (median: 24 months). Of 61 patients, 42 (69%) received neoadjuvant therapy prior to surgery. The overall resection rate was 95%. Significant post‐operative morbidity occurred in 47%, and the in‐hospital mortality was 5% (30‐day mortality: 3%). No overall survival benefit was seen in patients undergoing neoadjuvant therapy prior to surgical resection. However, patients who had a complete pathological response to neoadjuvant therapy had a better 5‐year survival than patients who did not receive neoadjuvant therapy: 47% versus 30%, respectively.
Conclusions: Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome.
| Original language | English |
|---|---|
| Pages (from-to) | 724-728 |
| Number of pages | 5 |
| Journal | ANZ Journal of Surgery |
| Volume | 79 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2009 |