Outcome following surgery for squamous cell carcinoma of the oesophagus

En Loon C Yong, Xing Peng Han, David I Watson, Peter G Devitt, Glyn G Jamieson, Sarah K Thompson

    Research output: Contribution to journalArticle

    13 Citations (Scopus)

    Abstract

    Introduction: This study was undertaken to determine the outcomes of patients treated for squamous cell carcinoma (SCC) of the oesophagus.

    Methods: The study group consisted of 61 patients (median age: 64 years) with invasive SCC of the oesophagus who underwent resection between 1987 and 2007 in Adelaide, South Australia. Thirty‐two (52%) were female. Survival data were available for all patients. The log rank test was performed to identify prognostic factors for survival.

    Results: The 5‐year overall survival rate was 33% (median: 24 months). Of 61 patients, 42 (69%) received neoadjuvant therapy prior to surgery. The overall resection rate was 95%. Significant post‐operative morbidity occurred in 47%, and the in‐hospital mortality was 5% (30‐day mortality: 3%). No overall survival benefit was seen in patients undergoing neoadjuvant therapy prior to surgical resection. However, patients who had a complete pathological response to neoadjuvant therapy had a better 5‐year survival than patients who did not receive neoadjuvant therapy: 47% versus 30%, respectively.

    Conclusions: Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome.
    Original languageEnglish
    Pages (from-to)724-728
    Number of pages5
    JournalANZ Journal of Surgery
    Volume79
    Issue number10
    DOIs
    Publication statusPublished - 2009

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