Outer membrane vesicle: A macromolecule with multifunctional activity

Arfa Moshiri; Abolfazl Dashtbani-Roozbehani; Shahin Najar Peerayeh; Seyed Davar Siadat

doi:10.4161/hv.20166

Outer membrane vesicle: A macromolecule with multifunctional activity

Arfa Moshiri, Abolfazl Dashtbani-Roozbehani, Shahin Najar Peerayeh, Seyed Davar Siadat

Research output: Contribution to journal › Comment/debate

16 Citations (Scopus)

Abstract

Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants. The outer membrane vesicle (OMV) of Neisseria meningitidis is among the newly studied components of microbial origin, which could be applied as an adjuvant. Although the potency of OMV as a carrier (conjugated to a hapten) is now proven, the adjuvant properties of OMV have particular significance as a potential target for protective immunity. Since it has immune-stimulatory activity, OMV has been utilized in vaccine development. This commentary reviews the different applications of OMV as potential adjuvant in the field of vaccine development.

Original language	English
Pages (from-to)	953-955
Number of pages	3
Journal	Human Vaccines & Immunotherapeutics
Volume	8
Issue number	7
DOIs	https://doi.org/10.4161/hv.20166
Publication status	Published - Jul 2012
Externally published	Yes

Keywords

Adjuvant
Neisseria meningitidis
Outer membrane vesicle
Vaccine development

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abstract = "Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants. The outer membrane vesicle (OMV) of Neisseria meningitidis is among the newly studied components of microbial origin, which could be applied as an adjuvant. Although the potency of OMV as a carrier (conjugated to a hapten) is now proven, the adjuvant properties of OMV have particular significance as a potential target for protective immunity. Since it has immune-stimulatory activity, OMV has been utilized in vaccine development. This commentary reviews the different applications of OMV as potential adjuvant in the field of vaccine development.",

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AU - Peerayeh, Shahin Najar

AU - Siadat, Seyed Davar

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AB - Nowadays adjuvants are extensively used as immuno-stimulatory and immuno-modulatory compounds as components of subunit and combination vaccine formulations. The adjuvants of microbial origin are more frequently used among currently used licensed or experimental adjuvants. The outer membrane vesicle (OMV) of Neisseria meningitidis is among the newly studied components of microbial origin, which could be applied as an adjuvant. Although the potency of OMV as a carrier (conjugated to a hapten) is now proven, the adjuvant properties of OMV have particular significance as a potential target for protective immunity. Since it has immune-stimulatory activity, OMV has been utilized in vaccine development. This commentary reviews the different applications of OMV as potential adjuvant in the field of vaccine development.

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Outer membrane vesicle: A macromolecule with multifunctional activity

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