Outsmarting superbugs: Bactericidal activity of nanostructured titanium surfaces against methicillin- and gentamicin-resistant Staphylococcus aureus ATCC 33592

Jason V. Wandiyanto, Samuel Cheeseman, Vi Khanh Truong, Mohammad Al Kobaisi, Chantal Bizet, Saulius Juodkazis, Helmut Thissen, Russell J. Crawford, Elena P. Ivanova

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The colonisation of biomaterial surfaces by pathogenic bacteria is a significant issue of concern, particularly in light of the rapid rise of antibiotic resistance. Current strategies are proving ineffective as multi-drug resistant pathogenic bacteria emerge. Recently, it was discovered that surfaces with nanoscale features are capable of physically rupturing bacteria and hence displaying mechano-bactericidal activity. In this study, we investigated the interactions between methicillin- and gentamicin-susceptible and -resistant Staphylococcus aureus strains and nanostructured titanium surfaces, fabricated using a hydrothermal etching process. The nanostructured titanium surfaces proved to be equally effective and highly bactericidal against both the susceptible and resistant S. aureus strains, with killing efficiencies of 80.7% ± 12.0 and 86.8% ± 11.6, respectively. The mechano-bactericidal activity of these nanostructured titanium surfaces offers an innovative solution to establish medical device surfaces with antimicrobial activity in the context of increasing antibiotic resistance.

Original languageEnglish
Pages (from-to)4424-4431
Number of pages8
JournalJOURNAL OF MATERIALS CHEMISTRY B
Volume7
Issue number28
DOIs
Publication statusPublished - 28 Jul 2019
Externally publishedYes

Keywords

  • Nanostructures
  • pathogenic bacteria
  • antibiotic resistance
  • Staphylococcus aureus ATCC 33592

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