TY - JOUR
T1 - Outsmarting superbugs
T2 - Bactericidal activity of nanostructured titanium surfaces against methicillin- and gentamicin-resistant Staphylococcus aureus ATCC 33592
AU - Wandiyanto, Jason V.
AU - Cheeseman, Samuel
AU - Truong, Vi Khanh
AU - Kobaisi, Mohammad Al
AU - Bizet, Chantal
AU - Juodkazis, Saulius
AU - Thissen, Helmut
AU - Crawford, Russell J.
AU - Ivanova, Elena P.
PY - 2019/7/28
Y1 - 2019/7/28
N2 - The colonisation of biomaterial surfaces by pathogenic bacteria is a significant issue of concern, particularly in light of the rapid rise of antibiotic resistance. Current strategies are proving ineffective as multi-drug resistant pathogenic bacteria emerge. Recently, it was discovered that surfaces with nanoscale features are capable of physically rupturing bacteria and hence displaying mechano-bactericidal activity. In this study, we investigated the interactions between methicillin- and gentamicin-susceptible and -resistant Staphylococcus aureus strains and nanostructured titanium surfaces, fabricated using a hydrothermal etching process. The nanostructured titanium surfaces proved to be equally effective and highly bactericidal against both the susceptible and resistant S. aureus strains, with killing efficiencies of 80.7% ± 12.0 and 86.8% ± 11.6, respectively. The mechano-bactericidal activity of these nanostructured titanium surfaces offers an innovative solution to establish medical device surfaces with antimicrobial activity in the context of increasing antibiotic resistance.
AB - The colonisation of biomaterial surfaces by pathogenic bacteria is a significant issue of concern, particularly in light of the rapid rise of antibiotic resistance. Current strategies are proving ineffective as multi-drug resistant pathogenic bacteria emerge. Recently, it was discovered that surfaces with nanoscale features are capable of physically rupturing bacteria and hence displaying mechano-bactericidal activity. In this study, we investigated the interactions between methicillin- and gentamicin-susceptible and -resistant Staphylococcus aureus strains and nanostructured titanium surfaces, fabricated using a hydrothermal etching process. The nanostructured titanium surfaces proved to be equally effective and highly bactericidal against both the susceptible and resistant S. aureus strains, with killing efficiencies of 80.7% ± 12.0 and 86.8% ± 11.6, respectively. The mechano-bactericidal activity of these nanostructured titanium surfaces offers an innovative solution to establish medical device surfaces with antimicrobial activity in the context of increasing antibiotic resistance.
KW - Nanostructures
KW - pathogenic bacteria
KW - antibiotic resistance
KW - Staphylococcus aureus ATCC 33592
UR - http://www.scopus.com/inward/record.url?scp=85069212364&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/ARC/IH130100017
U2 - 10.1039/c9tb00102f
DO - 10.1039/c9tb00102f
M3 - Article
AN - SCOPUS:85069212364
SN - 2050-7518
VL - 7
SP - 4424
EP - 4431
JO - Journal of materials chemistry. B
JF - Journal of materials chemistry. B
IS - 28
ER -