Overview of biomarkers in metastatic colorectal cancer: Tumour, blood and patient-related factors

Stephen Clarke, Christos Karapetis, Peter Gibbs, Nick Pavlakis, Jayesh Desai, Michael Michael, Niall Tebbutt, Timothy Price, J Tabernero

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    During the last 20 years there have been major therapeutic developments in colorectal cancer (CRC) with the introduction of multiple novel therapeutic agents into routine clinical practice. This has improved survival in both the adjuvant and advanced disease settings. However, improvements have come with substantial increases in expense to the community and potential toxicity to the patient. There has been substantial research to identify tumour factors in CRC that predict treatment response and survival outcomes. This research has identified clinically useful predictive biomarkers to aid clinical decision making, such as the presence or absence of KRAS gene mutations which can determine the benefit of using epidermal growth factor receptor (EGFR) inhibiting antibodies. However, less attention has been paid to the identification and impact of predictive patient-derived factors such as age, gender and the presence of comorbid conditions or evidence of a systemic inflammatory response. In this article, the current concepts of tumour and patient-related predictive factors in CRC management are reviewed.

    Original languageEnglish
    Pages (from-to)121-135
    Number of pages15
    JournalCritical Reviews in Oncology Hematology
    Volume85
    Issue number2
    DOIs
    Publication statusPublished - 2013

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