Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis

Panagiotis Paliogiannis, Alessandro G Fois, Claudia Collu, Antonietta Bandinu, Elisabetta Zinellu, Ciriaco Carru, Pietro Pirina, Arduino A Mangoni, Angelo Zinellu

Research output: Contribution to journalReview articlepeer-review

18 Citations (Scopus)


Aim: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. Methods: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. Results: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. Conclusion: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.

Original languageEnglish
Pages (from-to)1175-1184
Number of pages10
JournalBiomarkers in Medicine
Issue number10
Publication statusPublished - Oct 2018


  • bronchoalveolar lavage fluid
  • epithelial lining fluid
  • expired breath condensate
  • glutathione
  • hydroperoxides
  • idiopathic pulmonary fibrosis
  • isoprostanes
  • lung
  • oxidative stress
  • protein carbonyls
  • systemic
  • thiobarbituric acid reactive substances


Dive into the research topics of 'Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis: a systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this