TY - JOUR
T1 - Oxidative stress-linked biomarkers in idiopathic pulmonary fibrosis
T2 - a systematic review and meta-analysis
AU - Paliogiannis, Panagiotis
AU - Fois, Alessandro G
AU - Collu, Claudia
AU - Bandinu, Antonietta
AU - Zinellu, Elisabetta
AU - Carru, Ciriaco
AU - Pirina, Pietro
AU - Mangoni, Arduino A
AU - Zinellu, Angelo
PY - 2018/10
Y1 - 2018/10
N2 - Aim: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. Methods: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. Results: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. Conclusion: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.
AB - Aim: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. Methods: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. Results: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. Conclusion: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.
KW - bronchoalveolar lavage fluid
KW - epithelial lining fluid
KW - expired breath condensate
KW - glutathione
KW - hydroperoxides
KW - idiopathic pulmonary fibrosis
KW - isoprostanes
KW - lung
KW - oxidative stress
KW - protein carbonyls
KW - systemic
KW - thiobarbituric acid reactive substances
UR - http://www.scopus.com/inward/record.url?scp=85054462111&partnerID=8YFLogxK
U2 - 10.2217/bmm-2018-0108
DO - 10.2217/bmm-2018-0108
M3 - Review article
VL - 12
SP - 1175
EP - 1184
JO - Biomarkers in Medicine
JF - Biomarkers in Medicine
SN - 1752-0363
IS - 10
ER -