Abstract
Aim: The aim of this meta-analysis was to investigate associations between idiopathic pulmonary fibrosis (IPF) and markers of oxidative stress (OS) measured in different biological samples. Methods: A systematic search of publications listed in PubMed, Web of Science, Scopus and Google Scholar from inception to December 2017 was conducted. Results: Significant differences between IPF patients and controls were observed for all biomarkers (thiobarbituric acid reactive substances, hydroperoxides and glutathione), barring systemic isoprostanes. Conclusion: This meta-analysis showed a consistent increase in the concentrations of OS markers or a reduction in antioxidant markers, in patients with IPF, independent of the type of biological sample. Pending the results of further studies, OS biomarkers might be useful for the diagnosis and monitoring of IPF.
| Original language | English |
|---|---|
| Pages (from-to) | 1175-1184 |
| Number of pages | 10 |
| Journal | Biomarkers in Medicine |
| Volume | 12 |
| Issue number | 10 |
| Early online date | 7 Sept 2018 |
| DOIs | |
| Publication status | Published - Oct 2018 |
Keywords
- bronchoalveolar lavage fluid
- epithelial lining fluid
- expired breath condensate
- glutathione
- hydroperoxides
- idiopathic pulmonary fibrosis
- isoprostanes
- lung
- oxidative stress
- protein carbonyls
- systemic
- thiobarbituric acid reactive substances