Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis

Hope Uronis, Magnus Ekstrom, David Currow, D McCrory, G Samsa, Amy Abernethy

    Research output: Contribution to journalReview articlepeer-review

    35 Citations (Scopus)

    Abstract

    We searched MEDLINE, EMBASE and the Cochrane Controlled Trials Register to determine whether oxygen relieves dyspnoea in mildly or non-hypoxemic COPD and included 18 randomised controlled trials (431 participants) in the meta-analysis using Cochrane methodology. Oxygen therapy reduced dyspnoea when compared with medical air; standardised mean difference -0.37 (95% CI -0.50 to -0.24; I2=14%). In a priori subgroup and sensitivity analyses, dyspnoea was reduced by continuous oxygen during exertion but not short-burst oxygen therapy. Continuous exertional oxygen can relieve dyspnoea in mildly or non-hypoxemic COPD, but evidence from larger clinical trials is needed.

    Original languageEnglish
    Pages (from-to)492-494
    Number of pages3
    JournalThorax
    Volume70
    Issue number5
    DOIs
    Publication statusE-pub ahead of print - 2014

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