Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform

Jingxin Mo, Paul Eggers, Zhi-xiang Yuan, Colin Raston, Lee Yong Lim

    Research output: Contribution to journalArticlepeer-review

    34 Citations (Scopus)

    Abstract

    A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX-loaded PCV conjugated with alkyne-modified PEG-folic acid ligands prepared via click ligation (fP-PCV PTX) has enhanced potency against folate receptor (FR)-positive SKOV-3 ovarian tumour cells over FR-negative A549 lung tumour cells. Moreover, fP-PCV PTX is also four times more potent than the non-targeting PCV PTX platform towards SKOV-3 cells. Overall, as a delivery platform the PCVs have the potential to enhance efficacy of anticancer drugs by targeting a chemotherapeutic payload specifically to tumours and triggering the release of the encapsulated drug in the vicinity of cancer cells.

    Original languageEnglish
    Article number23489
    Number of pages12
    JournalScientific Reports
    Volume6
    Issue numberArt: 23489
    DOIs
    Publication statusPublished - 2016

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