Paclitaxel-loaded phosphonated calixarene nanovesicles as a modular drug delivery platform

Jingxin Mo, Paul Eggers, Zhi-xiang Yuan, Colin Raston, Lee Yong Lim

    Research output: Contribution to journalArticlepeer-review

    39 Citations (Scopus)


    A modular p-phosphonated calix[4]arene vesicle (PCV) loaded with paclitaxel (PTX) and conjugated with folic acid as a cancer targeting ligand has been prepared using a thin film-sonication method. It has a pH-responsive capacity to trigger the release of the encapsulated PTX payload under mildly acidic conditions. PTX-loaded PCV conjugated with alkyne-modified PEG-folic acid ligands prepared via click ligation (fP-PCV PTX) has enhanced potency against folate receptor (FR)-positive SKOV-3 ovarian tumour cells over FR-negative A549 lung tumour cells. Moreover, fP-PCV PTX is also four times more potent than the non-targeting PCV PTX platform towards SKOV-3 cells. Overall, as a delivery platform the PCVs have the potential to enhance efficacy of anticancer drugs by targeting a chemotherapeutic payload specifically to tumours and triggering the release of the encapsulated drug in the vicinity of cancer cells.

    Original languageEnglish
    Article number23489
    Number of pages12
    JournalScientific Reports
    Issue numberArt: 23489
    Publication statusPublished - 24 Mar 2016


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