Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao; Amanda Russell; Jonathan Beesley; Xiaoqing Chen; Sue Healey; Michelle Henderson; Mark Wong; Catherine Emmanuel; Laura Galletta; Sharon Johnatty; David Bowtell; Michelle Haber; Murray Norris; Paul Harnett; G Chenevix-Trench; Rosemary Balleine; Anna DeFazio; Dorota Gertig; Adele Green; Penelope Webb; Jillian Hung; Sue Moore; Nadia Traficante; Sian Fereday; Karen Harrap; Troy Sadkowsky; Nirmala Pandeya; Robin Stuart-Harris; Fred Kirsten; Josie Rutovitz; Peter Clingan; Amanda Glasgow; Anthony Proietto; Stephen Braye; Greg Otton; J Shannon; Tony Bonaventura; Stewart James; Stephen Begbie; Michael Friedlander; David Bell; Sally Baron-Hay; Alan Ferrier; Gregory Gard; David Nevell; Nick Pavlakis; Sue Valmadre; Barbara Young; Catherine Camaris; Roger Crouch; Lyndal Edwards; Neville Hacker; Donald Marsden; Greg Robertson; Philip Beale; Jane Beith; Jonothan Carter; Chris Dalrymple; Anne Hamilton; Roger Houghton; Peter Russell; Matthew Links; John Grygiel; Jane Hill; Alison Brand; K Byth; Richard Jaworski; Raghwa Sharma; Anita Achen; Gerard Wain; Bruce Ward; David Papadimos; Alex Crandon; Margaret Cummings; Ken Horwood; Andreas Obermair; Lew Perrin; David Wyld; James Nicklin; Margaret Davy; Martin Oehler; Christina Hall; Thomas Dodd; Tabitha Healy; Ken Pittman; Douglas Henderson; John Miller; John Pierdes; Penny Blomfield; David Challis; Robert McIntosh; Andrew Parker; Bob Brown; Robert Rome; David Allen; Peter Grant; Simon Hyde; Rohan Laurie; Melissa Robbie; David Healy; Thomas Jobling; Thomas Manolitsas; Jane McNealage; Peter Rogers; Beatrice Susil; Eric Sumithran; Ian Simpson; Kelly Phillips; Danny Rischin; Stephen Fox; Daryl Johnson; Paul Waring; Stephen Lade; Maurice Loughrey; Neil O'Callaghan; William Murray; Virginia Billson; Jan Pyman; Debra Neesham; Michael Quinn; Craig Underhill; Richard Bell; Leong Ng; R Blum; Vinod Ganju; Ian Hammond; Yee Leung; Anthony McCartney; Martin Buck; Izak Haviv; David Purdie; David Whiteman; Nikolajs Zeps; Mary Malt; Anne Mellon; Randall Robertson; Trish Vanden Bergh; Marian Jones; Patricia Mackenzie; Jane Maidens; Kathryn Nattress; Yoke Chiew; Annie Stenlake; Helen Sullivan; Barbara Alexander; Pat Ashover; Sue Brown; Tracy Corrish; Lyn Green; Lea Jackman; Kaltin Ferguson; Karen Martin; Adam Martyn; Barbara Ranieri; Joanne White; Victoria Jayde; Leanne Bowes; Pamela Mamers; Debra Giles; Joy Hendley; Allsopp Katherine; Trudy Schmidt; Helen Shirley; Colleen Ball; Cherry Young; Suzanna Viduka; Hoa Tran; Sanela Bilic; Lydia Galvinas; Julia Brooks

doi:10.1038/srep04669

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Bo Gao
, Amanda Russell
, Jonathan Beesley
, Xiaoqing Chen
, Sue Healey
, Michelle Henderson
, Mark Wong
, Catherine Emmanuel
, Laura Galletta
, Sharon Johnatty
, David Bowtell
, Michelle Haber
, Murray Norris
, Paul Harnett
, G Chenevix-Trench
, Rosemary Balleine
, Anna DeFazio
, Dorota Gertig
, Adele Green
, Penelope Webb

Jillian Hung, Sue Moore, Nadia Traficante, Sian Fereday, Karen Harrap, Troy Sadkowsky, Nirmala Pandeya, Robin Stuart-Harris, Fred Kirsten, Josie Rutovitz, Peter Clingan, Amanda Glasgow, Anthony Proietto, Stephen Braye, Greg Otton, J Shannon, Tony Bonaventura, Stewart James, Stephen Begbie, Michael Friedlander, David Bell, Sally Baron-Hay, Alan Ferrier, Gregory Gard, David Nevell, Nick Pavlakis, Sue Valmadre, Barbara Young, Catherine Camaris, Roger Crouch, Lyndal Edwards, Neville Hacker, Donald Marsden, Greg Robertson, Philip Beale, Jane Beith, Jonothan Carter, Chris Dalrymple, Anne Hamilton, Roger Houghton, Peter Russell, Matthew Links, John Grygiel, Jane Hill, Alison Brand, K Byth, Richard Jaworski, Raghwa Sharma, Anita Achen, Gerard Wain, Bruce Ward, David Papadimos, Alex Crandon, Margaret Cummings, Ken Horwood, Andreas Obermair, Lew Perrin, David Wyld, James Nicklin, Margaret Davy, Martin Oehler, Christina Hall, Thomas Dodd, Tabitha Healy, Ken Pittman, Douglas Henderson, John Miller, John Pierdes, Penny Blomfield, David Challis, Robert McIntosh, Andrew Parker, Bob Brown, Robert Rome, David Allen, Peter Grant, Simon Hyde, Rohan Laurie, Melissa Robbie, David Healy, Thomas Jobling, Thomas Manolitsas, Jane McNealage, Peter Rogers, Beatrice Susil, Eric Sumithran, Ian Simpson, Kelly Phillips, Danny Rischin, Stephen Fox, Daryl Johnson, Paul Waring, Stephen Lade, Maurice Loughrey, Neil O'Callaghan, William Murray, Virginia Billson, Jan Pyman, Debra Neesham, Michael Quinn, Craig Underhill, Richard Bell, Leong Ng, R Blum, Vinod Ganju, Ian Hammond, Yee Leung, Anthony McCartney, Martin Buck, Izak Haviv, David Purdie, David Whiteman, Nikolajs Zeps, Mary Malt, Anne Mellon, Randall Robertson, Trish Vanden Bergh, Marian Jones, Patricia Mackenzie, Jane Maidens, Kathryn Nattress, Yoke Chiew, Annie Stenlake, Helen Sullivan, Barbara Alexander, Pat Ashover, Sue Brown, Tracy Corrish, Lyn Green, Lea Jackman, Kaltin Ferguson, Karen Martin, Adam Martyn, Barbara Ranieri, Joanne White, Victoria Jayde, Leanne Bowes, Pamela Mamers, Debra Giles, Joy Hendley, Allsopp Katherine, Trudy Schmidt, Helen Shirley, Colleen Ball, Cherry Young, Suzanna Viduka, Hoa Tran, Sanela Bilic, Lydia Galvinas, Julia Brooks

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-free survival has been reported in patients with ovarian cancer. Variable paclitaxel clearance due to genotype specific differences in ABCB1 activity in cancer cells and/or normal tissues may underlie the association. Using cell-based models, we evaluated the correlations between ABCB1 expression, polymorphisms, transporter activity and paclitaxel sensitivity in ovarian cancer (n = 10) and lymphoblastoid (n = 19) cell lines. Close associations between ABCB1 expression, transporter function and paclitaxel sensitivity were found in lymphoblastoid cell lines, although we could not demonstrate an association with common SNPs. In ovarian cancer cell lines, ABCB1 expression was low and the association between expression and function was lost. These results suggest that ABCB1 related survival difference in ovarian cancer patients is more likely to be due to differential whole body paclitaxel clearance mediated by normal cells rather than a direct effect on cancer cells.

Original language	English
Article number	4669
Number of pages	9
Journal	Scientific Reports
Volume	4
Issue number	4669
DOIs	https://doi.org/10.1038/srep04669
Publication status	Published - 9 May 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1038/srep04669

Cite this

Gao, B., Russell, A., Beesley, J., Chen, X., Healey, S., Henderson, M., Wong, M., Emmanuel, C., Galletta, L., Johnatty, S., Bowtell, D., Haber, M., Norris, M., Harnett, P., Chenevix-Trench, G., Balleine, R., DeFazio, A., Gertig, D., Green, A., ... Brooks, J. (2014). Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer. Scientific Reports, 4(4669), Article 4669. https://doi.org/10.1038/srep04669

@article{c56d954db0254baab5513b1f389a5131,

title = "Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer",

abstract = "ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-free survival has been reported in patients with ovarian cancer. Variable paclitaxel clearance due to genotype specific differences in ABCB1 activity in cancer cells and/or normal tissues may underlie the association. Using cell-based models, we evaluated the correlations between ABCB1 expression, polymorphisms, transporter activity and paclitaxel sensitivity in ovarian cancer (n = 10) and lymphoblastoid (n = 19) cell lines. Close associations between ABCB1 expression, transporter function and paclitaxel sensitivity were found in lymphoblastoid cell lines, although we could not demonstrate an association with common SNPs. In ovarian cancer cell lines, ABCB1 expression was low and the association between expression and function was lost. These results suggest that ABCB1 related survival difference in ovarian cancer patients is more likely to be due to differential whole body paclitaxel clearance mediated by normal cells rather than a direct effect on cancer cells.",

author = "Bo Gao and Amanda Russell and Jonathan Beesley and Xiaoqing Chen and Sue Healey and Michelle Henderson and Mark Wong and Catherine Emmanuel and Laura Galletta and Sharon Johnatty and David Bowtell and Michelle Haber and Murray Norris and Paul Harnett and G Chenevix-Trench and Rosemary Balleine and Anna DeFazio and Dorota Gertig and Adele Green and Penelope Webb and Jillian Hung and Sue Moore and Nadia Traficante and Sian Fereday and Karen Harrap and Troy Sadkowsky and Nirmala Pandeya and Robin Stuart-Harris and Fred Kirsten and Josie Rutovitz and Peter Clingan and Amanda Glasgow and Anthony Proietto and Stephen Braye and Greg Otton and J Shannon and Tony Bonaventura and Stewart James and Stephen Begbie and Michael Friedlander and David Bell and Sally Baron-Hay and Alan Ferrier and Gregory Gard and David Nevell and Nick Pavlakis and Sue Valmadre and Barbara Young and Catherine Camaris and Roger Crouch and Lyndal Edwards and Neville Hacker and Donald Marsden and Greg Robertson and Philip Beale and Jane Beith and Jonothan Carter and Chris Dalrymple and Anne Hamilton and Roger Houghton and Peter Russell and Matthew Links and John Grygiel and Jane Hill and Alison Brand and K Byth and Richard Jaworski and Raghwa Sharma and Anita Achen and Gerard Wain and Bruce Ward and David Papadimos and Alex Crandon and Margaret Cummings and Ken Horwood and Andreas Obermair and Lew Perrin and David Wyld and James Nicklin and Margaret Davy and Martin Oehler and Christina Hall and Thomas Dodd and Tabitha Healy and Ken Pittman and Douglas Henderson and John Miller and John Pierdes and Penny Blomfield and David Challis and Robert McIntosh and Andrew Parker and Bob Brown and Robert Rome and David Allen and Peter Grant and Simon Hyde and Rohan Laurie and Melissa Robbie and David Healy and Thomas Jobling and Thomas Manolitsas and Jane McNealage and Peter Rogers and Beatrice Susil and Eric Sumithran and Ian Simpson and Kelly Phillips and Danny Rischin and Stephen Fox and Daryl Johnson and Paul Waring and Stephen Lade and Maurice Loughrey and Neil O'Callaghan and William Murray and Virginia Billson and Jan Pyman and Debra Neesham and Michael Quinn and Craig Underhill and Richard Bell and Leong Ng and R Blum and Vinod Ganju and Ian Hammond and Yee Leung and Anthony McCartney and Martin Buck and Izak Haviv and David Purdie and David Whiteman and Nikolajs Zeps and Mary Malt and Anne Mellon and Randall Robertson and \{Vanden Bergh\}, Trish and Marian Jones and Patricia Mackenzie and Jane Maidens and Kathryn Nattress and Yoke Chiew and Annie Stenlake and Helen Sullivan and Barbara Alexander and Pat Ashover and Sue Brown and Tracy Corrish and Lyn Green and Lea Jackman and Kaltin Ferguson and Karen Martin and Adam Martyn and Barbara Ranieri and Joanne White and Victoria Jayde and Leanne Bowes and Pamela Mamers and Debra Giles and Joy Hendley and Allsopp Katherine and Trudy Schmidt and Helen Shirley and Colleen Ball and Cherry Young and Suzanna Viduka and Hoa Tran and Sanela Bilic and Lydia Galvinas and Julia Brooks",

year = "2014",

month = may,

day = "9",

doi = "10.1038/srep04669",

language = "English",

volume = "4",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "4669",

}

Gao, B, Russell, A, Beesley, J, Chen, X, Healey, S, Henderson, M, Wong, M, Emmanuel, C, Galletta, L, Johnatty, S, Bowtell, D, Haber, M, Norris, M, Harnett, P, Chenevix-Trench, G, Balleine, R, DeFazio, A, Gertig, D, Green, A, Webb, P, Hung, J, Moore, S, Traficante, N, Fereday, S, Harrap, K, Sadkowsky, T, Pandeya, N, Stuart-Harris, R, Kirsten, F, Rutovitz, J, Clingan, P, Glasgow, A, Proietto, A, Braye, S, Otton, G, Shannon, J, Bonaventura, T, James, S, Begbie, S, Friedlander, M, Bell, D, Baron-Hay, S, Ferrier, A, Gard, G, Nevell, D, Pavlakis, N, Valmadre, S, Young, B, Camaris, C, Crouch, R, Edwards, L, Hacker, N, Marsden, D, Robertson, G, Beale, P, Beith, J, Carter, J, Dalrymple, C, Hamilton, A, Houghton, R, Russell, P, Links, M, Grygiel, J, Hill, J, Brand, A, Byth, K, Jaworski, R, Sharma, R, Achen, A, Wain, G, Ward, B, Papadimos, D, Crandon, A, Cummings, M, Horwood, K, Obermair, A, Perrin, L, Wyld, D, Nicklin, J, Davy, M, Oehler, M, Hall, C, Dodd, T, Healy, T, Pittman, K, Henderson, D, Miller, J, Pierdes, J, Blomfield, P, Challis, D, McIntosh, R, Parker, A, Brown, B, Rome, R, Allen, D, Grant, P, Hyde, S, Laurie, R, Robbie, M, Healy, D, Jobling, T, Manolitsas, T, McNealage, J, Rogers, P, Susil, B, Sumithran, E, Simpson, I, Phillips, K, Rischin, D, Fox, S, Johnson, D, Waring, P, Lade, S, Loughrey, M, O'Callaghan, N, Murray, W, Billson, V, Pyman, J, Neesham, D, Quinn, M, Underhill, C, Bell, R, Ng, L, Blum, R, Ganju, V, Hammond, I, Leung, Y, McCartney, A, Buck, M, Haviv, I, Purdie, D, Whiteman, D, Zeps, N, Malt, M, Mellon, A, Robertson, R, Vanden Bergh, T, Jones, M, Mackenzie, P, Maidens, J, Nattress, K, Chiew, Y, Stenlake, A, Sullivan, H, Alexander, B, Ashover, P, Brown, S, Corrish, T, Green, L, Jackman, L, Ferguson, K, Martin, K, Martyn, A, Ranieri, B, White, J, Jayde, V, Bowes, L, Mamers, P, Giles, D, Hendley, J, Katherine, A, Schmidt, T, Shirley, H, Ball, C, Young, C, Viduka, S, Tran, H, Bilic, S, Galvinas, L & Brooks, J 2014, 'Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer', Scientific Reports, vol. 4, no. 4669, 4669. https://doi.org/10.1038/srep04669

TY - JOUR

T1 - Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

AU - Gao, Bo

AU - Russell, Amanda

AU - Beesley, Jonathan

AU - Chen, Xiaoqing

AU - Healey, Sue

AU - Henderson, Michelle

AU - Wong, Mark

AU - Emmanuel, Catherine

AU - Galletta, Laura

AU - Johnatty, Sharon

AU - Bowtell, David

AU - Haber, Michelle

AU - Norris, Murray

AU - Harnett, Paul

AU - Chenevix-Trench, G

AU - Balleine, Rosemary

AU - DeFazio, Anna

AU - Gertig, Dorota

AU - Green, Adele

AU - Webb, Penelope

AU - Hung, Jillian

AU - Moore, Sue

AU - Traficante, Nadia

AU - Fereday, Sian

AU - Harrap, Karen

AU - Sadkowsky, Troy

AU - Pandeya, Nirmala

AU - Stuart-Harris, Robin

AU - Kirsten, Fred

AU - Rutovitz, Josie

AU - Clingan, Peter

AU - Glasgow, Amanda

AU - Proietto, Anthony

AU - Braye, Stephen

AU - Otton, Greg

AU - Shannon, J

AU - Bonaventura, Tony

AU - James, Stewart

AU - Begbie, Stephen

AU - Friedlander, Michael

AU - Bell, David

AU - Baron-Hay, Sally

AU - Ferrier, Alan

AU - Gard, Gregory

AU - Nevell, David

AU - Pavlakis, Nick

AU - Valmadre, Sue

AU - Young, Barbara

AU - Camaris, Catherine

AU - Crouch, Roger

AU - Edwards, Lyndal

AU - Hacker, Neville

AU - Marsden, Donald

AU - Robertson, Greg

AU - Beale, Philip

AU - Beith, Jane

AU - Carter, Jonothan

AU - Dalrymple, Chris

AU - Hamilton, Anne

AU - Houghton, Roger

AU - Russell, Peter

AU - Links, Matthew

AU - Grygiel, John

AU - Hill, Jane

AU - Brand, Alison

AU - Byth, K

AU - Jaworski, Richard

AU - Sharma, Raghwa

AU - Achen, Anita

AU - Wain, Gerard

AU - Ward, Bruce

AU - Papadimos, David

AU - Crandon, Alex

AU - Cummings, Margaret

AU - Horwood, Ken

AU - Obermair, Andreas

AU - Perrin, Lew

AU - Wyld, David

AU - Nicklin, James

AU - Davy, Margaret

AU - Oehler, Martin

AU - Hall, Christina

AU - Dodd, Thomas

AU - Healy, Tabitha

AU - Pittman, Ken

AU - Henderson, Douglas

AU - Miller, John

AU - Pierdes, John

AU - Blomfield, Penny

AU - Challis, David

AU - McIntosh, Robert

AU - Parker, Andrew

AU - Brown, Bob

AU - Rome, Robert

AU - Allen, David

AU - Grant, Peter

AU - Hyde, Simon

AU - Laurie, Rohan

AU - Robbie, Melissa

AU - Healy, David

AU - Jobling, Thomas

AU - Manolitsas, Thomas

AU - McNealage, Jane

AU - Rogers, Peter

AU - Susil, Beatrice

AU - Sumithran, Eric

AU - Simpson, Ian

AU - Phillips, Kelly

AU - Rischin, Danny

AU - Fox, Stephen

AU - Johnson, Daryl

AU - Waring, Paul

AU - Lade, Stephen

AU - Loughrey, Maurice

AU - O'Callaghan, Neil

AU - Murray, William

AU - Billson, Virginia

AU - Pyman, Jan

AU - Neesham, Debra

AU - Quinn, Michael

AU - Underhill, Craig

AU - Bell, Richard

AU - Ng, Leong

AU - Blum, R

AU - Ganju, Vinod

AU - Hammond, Ian

AU - Leung, Yee

AU - McCartney, Anthony

AU - Buck, Martin

AU - Haviv, Izak

AU - Purdie, David

AU - Whiteman, David

AU - Zeps, Nikolajs

AU - Malt, Mary

AU - Mellon, Anne

AU - Robertson, Randall

AU - Vanden Bergh, Trish

AU - Jones, Marian

AU - Mackenzie, Patricia

AU - Maidens, Jane

AU - Nattress, Kathryn

AU - Chiew, Yoke

AU - Stenlake, Annie

AU - Sullivan, Helen

AU - Alexander, Barbara

AU - Ashover, Pat

AU - Brown, Sue

AU - Corrish, Tracy

AU - Green, Lyn

AU - Jackman, Lea

AU - Ferguson, Kaltin

AU - Martin, Karen

AU - Martyn, Adam

AU - Ranieri, Barbara

AU - White, Joanne

AU - Jayde, Victoria

AU - Bowes, Leanne

AU - Mamers, Pamela

AU - Giles, Debra

AU - Hendley, Joy

AU - Katherine, Allsopp

AU - Schmidt, Trudy

AU - Shirley, Helen

AU - Ball, Colleen

AU - Young, Cherry

AU - Viduka, Suzanna

AU - Tran, Hoa

AU - Bilic, Sanela

AU - Galvinas, Lydia

AU - Brooks, Julia

PY - 2014/5/9

Y1 - 2014/5/9

N2 - ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-free survival has been reported in patients with ovarian cancer. Variable paclitaxel clearance due to genotype specific differences in ABCB1 activity in cancer cells and/or normal tissues may underlie the association. Using cell-based models, we evaluated the correlations between ABCB1 expression, polymorphisms, transporter activity and paclitaxel sensitivity in ovarian cancer (n = 10) and lymphoblastoid (n = 19) cell lines. Close associations between ABCB1 expression, transporter function and paclitaxel sensitivity were found in lymphoblastoid cell lines, although we could not demonstrate an association with common SNPs. In ovarian cancer cell lines, ABCB1 expression was low and the association between expression and function was lost. These results suggest that ABCB1 related survival difference in ovarian cancer patients is more likely to be due to differential whole body paclitaxel clearance mediated by normal cells rather than a direct effect on cancer cells.

AB - ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-free survival has been reported in patients with ovarian cancer. Variable paclitaxel clearance due to genotype specific differences in ABCB1 activity in cancer cells and/or normal tissues may underlie the association. Using cell-based models, we evaluated the correlations between ABCB1 expression, polymorphisms, transporter activity and paclitaxel sensitivity in ovarian cancer (n = 10) and lymphoblastoid (n = 19) cell lines. Close associations between ABCB1 expression, transporter function and paclitaxel sensitivity were found in lymphoblastoid cell lines, although we could not demonstrate an association with common SNPs. In ovarian cancer cell lines, ABCB1 expression was low and the association between expression and function was lost. These results suggest that ABCB1 related survival difference in ovarian cancer patients is more likely to be due to differential whole body paclitaxel clearance mediated by normal cells rather than a direct effect on cancer cells.

UR - https://www.scopus.com/pages/publications/84901049508

U2 - 10.1038/srep04669

DO - 10.1038/srep04669

M3 - Article

SN - 2045-2322

VL - 4

JO - Scientific Reports

JF - Scientific Reports

IS - 4669

M1 - 4669

ER -

Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this