Pain-Causing Venom Peptides: Insights into Sensory Neuron Pharmacology.

Jami Sina, Andelain Erickson, Stuart Brierley, Irina Vetter

Research output: Contribution to journalReview articlepeer-review

14 Citations (Scopus)

Abstract

Venoms are produced by a wide variety of species including spiders, scorpions, reptiles, cnidarians, and fish for the purpose of harming or incapacitating predators or prey. While some venoms are of relatively simple composition, many contain hundreds to thousands of individual components with distinct pharmacological activity. Pain-inducing or “algesic” venom compounds have proven invaluable to our understanding of how physiological nociceptive neural networks operate. In this review, we present an overview of some of the diverse nociceptive pathways that can be modulated by specific venom components to evoke pain.

Original languageEnglish
Number of pages15
JournalToxins
Volume10
Issue number1
DOIs
Publication statusPublished - Jan 2018

Keywords

  • Animal venom
  • ASIC
  • Pain
  • Pore forming toxin
  • Sodium channel
  • TRP channel

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