Palaeopathology of the earlobe crease (Frank's sign): New insights from Renaissance art

Francesco M Galassi, Claudio Borghi, Roberta Ballestriero, Michael Habicht, Maciej Henneberg, Frank Ruhli

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Several studies have associated the earlobe crease sign, discovered by Sanders T. Frank in 1973, with cardiovascular pathology, yet very few studies have focused on the antiquity of this trait, with the most ancient one thought to date back to the Roman Emperor Hadrian (76–138 CE). This article presents two more cases from the Italian Renaissance in the works of the artist Andrea Mantegna (1431–1506) and examines them in a multidisciplinary fashion.

Original languageEnglish
Pages (from-to)82-84
Number of pages3
JournalInternational Journal of Cardiology
Publication statusPublished - 1 Jun 2017


  • Cardiovascular pathology
  • Earlobe crease
  • Frank's sign
  • Mantegna
  • Palaeopathology
  • Prevention
  • Renaissance


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