Pallidotomy does not ameliorate abnormal intracortical inhibition in Parkinson's disease

Martin Sale, Michael Nordstrom, Brian Brophy, Philip Thompson

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    Abstract

    Motor cortex excitability was assessed in 12 patients with Parkinson's disease (PD) using transcranial magnetic stimulation. Patients were studied when mobile and medicated ("ON") and when immobile after medication withdrawal ("OFF"). Results were compared to eight age-matched and 11 young controls. Cortical excitability was assessed by measurement of resting motor threshold (RMT), intracortical inhibition and cortical silent period duration. In five patients, the studies included assessments following pallidotomy. Cortical excitability was abnormal in patients with PD with reduced RMT in "ON" and "OFF" states, and less effective intracortical inhibition. Pallidotomy did not affect cortical excitability in either "ON" or "OFF" states, indicating that enhanced motor cortex excitability in patients with PD is unaffected by pallidotomy despite clinical improvement in motor scores.

    Original languageEnglish
    Pages (from-to)711-716
    Number of pages6
    JournalJournal of Clinical Neuroscience
    Volume17
    Issue number6
    DOIs
    Publication statusPublished - Jun 2010

    Keywords

    • Intracortical inhibition
    • Motor cortex
    • Pallidotomy
    • Parkinson's disease
    • TMS

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