Paracetamol metabolism in pregnancy.

JO Miners, RA Robson, DJ Birkett

    Research output: Contribution to journalArticlepeer-review

    59 Citations (Scopus)

    Abstract

    Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

    Original languageEnglish
    Pages (from-to)359-362
    Number of pages4
    JournalBritish Journal of Clinical Pharmacology
    Volume22
    Issue number3
    DOIs
    Publication statusPublished - Sep 1986

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