Paracetamol metabolism in pregnancy.

JO Miners; RA Robson; DJ Birkett

doi:10.1111/j.1365-2125.1986.tb02901.x

Paracetamol metabolism in pregnancy.

JO Miners, RA Robson, DJ Birkett

Research output: Contribution to journal › Article › peer-review

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Abstract

Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

Original language	English
Pages (from-to)	359-362
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1986.tb02901.x
Publication status	Published - Sept 1986

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AB - Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

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Paracetamol metabolism in pregnancy.

Abstract

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