Abstract
Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society
Original language | English |
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Pages (from-to) | 359-362 |
Number of pages | 4 |
Journal | British Journal of Clinical Pharmacology |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - Sept 1986 |