Paracetamol metabolism in pregnancy.

JO Miners; RA Robson; DJ Birkett

doi:10.1111/j.1365-2125.1986.tb02901.x

Paracetamol metabolism in pregnancy.

JO Miners, RA Robson, DJ Birkett

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

Original language	English
Pages (from-to)	359-362
Number of pages	4
Journal	British Journal of Clinical Pharmacology
Volume	22
Issue number	3
DOIs	https://doi.org/10.1111/j.1365-2125.1986.tb02901.x
Publication status	Published - Sept 1986

Access to Document

10.1111/j.1365-2125.1986.tb02901.xLicence: In Copyright

Cite this

@article{c2ca9ab0ed8d475bb84bd98a8de33d3f,

title = "Paracetamol metabolism in pregnancy.",

abstract = "Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society",

author = "JO Miners and RA Robson and DJ Birkett",

year = "1986",

month = sep,

doi = "10.1111/j.1365-2125.1986.tb02901.x",

language = "English",

volume = "22",

pages = "359--362",

journal = "British Journal of Clinical Pharmacology",

issn = "0306-5251",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Paracetamol metabolism in pregnancy.

AU - Miners, JO

AU - Robson, RA

AU - Birkett, DJ

PY - 1986/9

Y1 - 1986/9

N2 - Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

AB - Paracetamol disposition was studied in groups of pregnant and non‐ pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half‐life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug. 1986 The British Pharmacological Society

UR - http://www.scopus.com/inward/record.url?scp=0022997361&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2125.1986.tb02901.x

DO - 10.1111/j.1365-2125.1986.tb02901.x

M3 - Article

C2 - 3768250

AN - SCOPUS:0022997361

SN - 0306-5251

VL - 22

SP - 359

EP - 362

JO - British Journal of Clinical Pharmacology

JF - British Journal of Clinical Pharmacology

IS - 3

ER -

Paracetamol metabolism in pregnancy.

Abstract

Access to Document

Other files and links

Fingerprint

Cite this