Paraoxonase-1 in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Elisabetta Zinellu; Angelo Zinellu; Maria C. Pau; Alessandro G. Fois; Sabrina Mellino; Arduino A. Mangoni; Ciriaco Carru; Pietro Pirina

doi:10.23736/S2784-8477.22.01999-4

Paraoxonase-1 in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Elisabetta Zinellu, Angelo Zinellu, Maria C. Pau, Alessandro G. Fois, Sabrina Mellino, Arduino A. Mangoni, Ciriaco Carru, Pietro Pirina

College of Medicine and Public Health

Research output: Contribution to journal › Review article › peer-review

1 Citation (Scopus)

Abstract

INTRODUCTION: Oxidative stress plays a critical pathophysiological role in chronic obstructive pulmonary diseas (COPD). An impairment in antioxidant defense systems, which include the enzyme paraoxonase1 (PON-1), have bee reported in COPD patients. This systematic review and meta-analysis investigated the association between serum PON and COPD.

EVIDENCE ACQUISITION: A systematic search was performed using the following terms and their combination “paraoxonase-1” or “PON-1” and “chronic obstructive pulmonary disease” or “COPD” in PubMed, Web of Science Scopus, and Google Scholar, from inception to October 2021. Standardized mean differences (SMDs) of serum PONconcentrations between stable COPD patients and non-COPD subjects were calculated.

EVIDENCE SYNTHESIS: Thirteen studies were included in the meta-analysis. Pooled results showed that serum PONconcentrations were significantly lower in patients with COPD (SMD=-1.12, 95% CI: -1.72 to -0.53; P<0.001).

CONCLUSIONS: The observed reduction of PON-1 concentrations in COPD patients supports the presence of an impaired antioxidant defense system in this group.

Original language	English
Pages (from-to)	138-145
Number of pages	8
Journal	Minerva Respiratory Medicine
Volume	61
Issue number	3
Early online date	2 Aug 2022
DOIs	https://doi.org/10.23736/S2784-8477.22.01999-4
Publication status	Published - Sept 2022

Keywords

Oxidative stress
Pulmonary disease, chronic obstructive
Systematic review

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title = "Paraoxonase-1 in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis",

abstract = "INTRODUCTION: Oxidative stress plays a critical pathophysiological role in chronic obstructive pulmonary diseas (COPD). An impairment in antioxidant defense systems, which include the enzyme paraoxonase1 (PON-1), have bee reported in COPD patients. This systematic review and meta-analysis investigated the association between serum PON and COPD.EVIDENCE ACQUISITION: A systematic search was performed using the following terms and their combination “paraoxonase-1” or “PON-1” and “chronic obstructive pulmonary disease” or “COPD” in PubMed, Web of Science Scopus, and Google Scholar, from inception to October 2021. Standardized mean differences (SMDs) of serum PONconcentrations between stable COPD patients and non-COPD subjects were calculated. EVIDENCE SYNTHESIS: Thirteen studies were included in the meta-analysis. Pooled results showed that serum PONconcentrations were significantly lower in patients with COPD (SMD=-1.12, 95% CI: -1.72 to -0.53; P<0.001). CONCLUSIONS: The observed reduction of PON-1 concentrations in COPD patients supports the presence of an impaired antioxidant defense system in this group. ",

keywords = "Oxidative stress, Pulmonary disease, chronic obstructive, Systematic review",

author = "Elisabetta Zinellu and Angelo Zinellu and Pau, {Maria C.} and Fois, {Alessandro G.} and Sabrina Mellino and Mangoni, {Arduino A.} and Ciriaco Carru and Pietro Pirina",

year = "2022",

month = sep,

doi = "10.23736/S2784-8477.22.01999-4",

language = "English",

volume = "61",

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TY - JOUR

T1 - Paraoxonase-1 in stable chronic obstructive pulmonary disease

T2 - a systematic review and meta-analysis

AU - Zinellu, Elisabetta

AU - Zinellu, Angelo

AU - Pau, Maria C.

AU - Fois, Alessandro G.

AU - Mellino, Sabrina

AU - Mangoni, Arduino A.

AU - Carru, Ciriaco

AU - Pirina, Pietro

PY - 2022/9

Y1 - 2022/9

N2 - INTRODUCTION: Oxidative stress plays a critical pathophysiological role in chronic obstructive pulmonary diseas (COPD). An impairment in antioxidant defense systems, which include the enzyme paraoxonase1 (PON-1), have bee reported in COPD patients. This systematic review and meta-analysis investigated the association between serum PON and COPD.EVIDENCE ACQUISITION: A systematic search was performed using the following terms and their combination “paraoxonase-1” or “PON-1” and “chronic obstructive pulmonary disease” or “COPD” in PubMed, Web of Science Scopus, and Google Scholar, from inception to October 2021. Standardized mean differences (SMDs) of serum PONconcentrations between stable COPD patients and non-COPD subjects were calculated. EVIDENCE SYNTHESIS: Thirteen studies were included in the meta-analysis. Pooled results showed that serum PONconcentrations were significantly lower in patients with COPD (SMD=-1.12, 95% CI: -1.72 to -0.53; P<0.001). CONCLUSIONS: The observed reduction of PON-1 concentrations in COPD patients supports the presence of an impaired antioxidant defense system in this group.

AB - INTRODUCTION: Oxidative stress plays a critical pathophysiological role in chronic obstructive pulmonary diseas (COPD). An impairment in antioxidant defense systems, which include the enzyme paraoxonase1 (PON-1), have bee reported in COPD patients. This systematic review and meta-analysis investigated the association between serum PON and COPD.EVIDENCE ACQUISITION: A systematic search was performed using the following terms and their combination “paraoxonase-1” or “PON-1” and “chronic obstructive pulmonary disease” or “COPD” in PubMed, Web of Science Scopus, and Google Scholar, from inception to October 2021. Standardized mean differences (SMDs) of serum PONconcentrations between stable COPD patients and non-COPD subjects were calculated. EVIDENCE SYNTHESIS: Thirteen studies were included in the meta-analysis. Pooled results showed that serum PONconcentrations were significantly lower in patients with COPD (SMD=-1.12, 95% CI: -1.72 to -0.53; P<0.001). CONCLUSIONS: The observed reduction of PON-1 concentrations in COPD patients supports the presence of an impaired antioxidant defense system in this group.

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Paraoxonase-1 in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

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