Partial characterization of a cell-free hemolytic factor produced by Helicobacter pylori

B. L. Wetherall, P. J. McDonald, A. M. Johnson

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Maximum cell-free hemolytic activity of Helicobacter pylori cultured in broth containing 10% horse serum occurred only after the stationary phase of growth was reached, unlike many hemolysins produced by Gram-negative bacteria which are active during exponential growth. This characteristic of the H. pylori hemolytic factor suggested that it might also possess protease activity. However, because no evidence of albumin degradation was found, the hemolysis by cell-free concentrates of H. pylori appears to be due to a unique factor derived from the organism. Because variable hemolysis results were obtained with culture broths lacking albumin or serum, these proteins may act as carriers or stabilizers of the putative hemolysin.

    Original languageEnglish
    Pages (from-to)123-128
    Number of pages6
    JournalFEMS Microbiology Letters
    Volume89
    Issue number3
    DOIs
    Publication statusPublished - Feb 1992

    Keywords

    • Helicobacter pylori
    • Hemolytic activity

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