Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea

Paul R. Badenoch, Alan M. Johnson, Peter E. Christy, Douglas J. Coster

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Acanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalArchives of Ophthalmology
Issue number1
Publication statusPublished - Jan 1990
Externally publishedYes


Dive into the research topics of 'Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea'. Together they form a unique fingerprint.

Cite this