Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea

Paul R. Badenoch; Alan M. Johnson; Peter E. Christy; Douglas J. Coster

doi:10.1001/archopht.1990.01070030113040

Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea

Paul R. Badenoch, Alan M. Johnson, Peter E. Christy, Douglas J. Coster

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Acanthamoeba keratitis is a sight-threatening disease that is difficult to treat. The development of an animal model is necessary for many of the studies required to improve visual outcome in human patients. A rat model is proposed that is dependent on coinoculation of amebae and corynebacteria into the corneal stroma. The infective dose was determined for a virulent Acanthamoeba isolate and was used to screen 17 other isolates, including 7 from the human cornea. A total of 6 were infective in the rat cornea. The model should be useful for controlled in vivo studies of this intractable condition.

Original language	English
Pages (from-to)	107-112
Number of pages	6
Journal	Archives of Ophthalmology
Volume	108
Issue number	1
DOIs	https://doi.org/10.1001/archopht.1990.01070030113040
Publication status	Published - Jan 1990
Externally published	Yes

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Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea

Abstract

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