Pathophysiology & genetics of obstructive sleep apnoea

Lisa M. Campana, Danny J. Eckert, Sanjay Rajnikant Patel, Atul Malhotra

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Obstructive sleep apnoea (OSA) is a highly prevalent condition with proven neurocognitive and cardiovascular consequences. OSA patients experience repetitive narrowing or collapse of the pharyngeal airway during sleep. Multiple factors likely underlie the pathophysiology of this condition with considerable inter-individual variation. Important risk factors for OSA include obesity, male gender, and ageing. However, the mechanisms underlying these major risk factors are not well understood. We briefly review the state-of-the-art knowledge regarding OSA pathogenesis in adults and highlight the potential role of genetics in influencing key OSA pathophysiological traits.

Original languageEnglish
Pages (from-to)176-187
Number of pages12
JournalINDIAN JOURNAL OF MEDICAL RESEARCH
Volume131
Issue number2
Publication statusPublished - 2010

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    Campana, L. M., Eckert, D. J., Patel, S. R., & Malhotra, A. (2010). Pathophysiology & genetics of obstructive sleep apnoea. INDIAN JOURNAL OF MEDICAL RESEARCH, 131(2), 176-187.