Pathophysiology of upper airway collapse

Jayne C. Carberry; Jane E. Butler; Danny J. Eckert

doi:10.2217/EBO.13.343

Pathophysiology of upper airway collapse

Jayne C. Carberry, Jane E. Butler, Danny J. Eckert

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Obstructive sleep apnea is characterized by repetitive episodes of upper airway collapse (lasting ≥10 s) during sleep. This leads to partial (hypopnea) or complete (apnea) cessation of airflow and blood gas disturbances (hypoxia and hypercapnia), despite ongoing respiratory efforts. Restoration of upper airway patency typically results in a brief awakening (arousal) from sleep. The repetitive physiological stress of obstructive sleep apnea can lead to sleep fragmentation with consequential excessive daytime sleepiness, neurocognitive and cardiovascular sequelae.

Original language	English
Title of host publication	Novel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea
Editors	Patrick Levy
Publisher	Future Medicine Ltd.
Chapter	2
Pages	23-33
Number of pages	11
ISBN (Electronic)	9781780842103, 978-1-78084-211-0
ISBN (Print)	978-1-78084-212-7
DOIs	https://doi.org/10.2217/EBO.13.343
Publication status	Published - 3 Apr 2014
Externally published	Yes

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