Pathophysiology of upper airway collapse

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obstructive sleep apnea is characterized by repetitive episodes of upper airway collapse (lasting ≥10 s) during sleep. This leads to partial (hypopnea) or complete (apnea) cessation of airflow and blood gas disturbances (hypoxia and hypercapnia), despite ongoing respiratory efforts. Restoration of upper airway patency typically results in a brief awakening (arousal) from sleep. The repetitive physiological stress of obstructive sleep apnea can lead to sleep fragmentation with consequential excessive daytime sleepiness, neurocognitive and cardiovascular sequelae.
Original languageEnglish
Title of host publicationNovel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea
EditorsPatrick Levy
PublisherFuture Medicine Ltd.
Chapter2
Pages23-33
Number of pages11
ISBN (Electronic)9781780842103, 978-1-78084-211-0
ISBN (Print)978-1-78084-212-7
DOIs
Publication statusPublished - 3 Apr 2014
Externally publishedYes

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  • Cite this

    Carberry, J. C., Butler, J. E., & Eckert, D. J. (2014). Pathophysiology of upper airway collapse. In P. Levy (Ed.), Novel Insights into the Pathophysiology and Treatment of Obstructive Sleep Apnea (pp. 23-33). Future Medicine Ltd.. https://doi.org/10.2217/EBO.13.343