Patient Perspectives on the Meaning and Impact of Fatigue in Hemodialysis: A Systematic Review and Thematic Analysis of Qualitative Studies

Jack Jacobson, Angela Ju, Amanda Baumgart, Mark Unruh, Donal O'Donoghue, Gregorio Obrador, Jonathan C. Craig, Juan M. Dapueto, Mary Amanda Dew, Michael Germain, Richard Fluck, Sara N. Davison, Sarbjit Vanita Jassal, Karine Manera, Alice C. Smith, Allison Tong

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)


Rationale & Objective: Fatigue is a highly prevalent and debilitating symptom in patients on hemodialysis therapy due to the uremic milieu, the hemodialysis treatment itself, and other comorbid conditions. However, fatigue remains underrecognized and the consequences are underappreciated because it may not be visible in clinical settings. This study aims to describe the experience that patients undergoing maintenance hemodialysis have with fatigue.

Study Design: Systematic review and thematic synthesis of qualitative studies. Setting & Study Populations: Patients undergoing hemodialysis.

Search Strategy & Sources: MEDLINE, Embase, PsycINFO, CINAHL, reference lists, and PhD dissertations were searched from inception to October 2018.

Data Extraction: All text from the results/conclusion of the primary studies. Analytical Approach: Thematic synthesis.

Results: 65 studies involving 1,713 participants undergoing hemodialysis were included. We identified 4 themes related to fatigue: debilitating and exhausting burden of dialysis (bodily depletion, trapped in a vicious cycle of postdialysis exhaustion, vigilance and worry inhibiting rest, tiresome and agonizing regimen, and without remedy and relief), restricted life participation (deprived of time, managing energy reserves, frustrating need to rest, and joys foregone), diminishing capacities to fulfil relationship roles (losing ability to work and provide for family, failing as a parent, lacking stamina for sexual intimacy, and relying on others), and vulnerable to misunderstanding (being criticized for the need to rest and failing to meet expectations).

Limitations: Non-English articles were excluded and most studies were conducted in high-income countries.

Conclusions: For patients undergoing hemodialysis who experience fatigue, fatigue is a profound and relentless exhaustion that pervades the entire body and encompasses weakness. The fatigue drains vitality in patients and constrains their ability to do usual activities and fulfill their roles and meet personal aspirations. Explicit recognition of the impact of fatigue and establishing additional effective interventions to improve fatigue are needed.

Original languageEnglish
Pages (from-to)179-192
Number of pages14
JournalAmerican Journal of Kidney Diseases
Issue number2
Publication statusPublished - 1 Aug 2019


  • chronic disease
  • dialysis
  • end-stage kidney disease (ESKD)
  • exhaustion
  • Fatigue
  • hemodialysis (HD)
  • lack of energy
  • outcomes
  • patient-centered care
  • patient-reported outcome measure (PROM)
  • postdialysis fatigue
  • qualitative research
  • quality of life (QoL)
  • systematic review
  • tiredness
  • weakness


Dive into the research topics of 'Patient Perspectives on the Meaning and Impact of Fatigue in Hemodialysis: A Systematic Review and Thematic Analysis of Qualitative Studies'. Together they form a unique fingerprint.

Cite this