Patterns of care and outcomes for gastric and gastro-oesophageal junction cancer in an Australian population

M. Nazim Abbas, Tim Bright, Timothy Price, Christos Karapetis, Sarah Thompson, Caroline Connell, David Watson, Mary Barnes, Jeff Bull, Nimit Singhal, Amitesh Roy

Research output: Contribution to journalArticlepeer-review

Abstract

Background: A single state-wide upper gastrointestinal (GI) cancer video-linked multidisciplinary team (MDT) meeting guides management and evidence-based care for all newly diagnosed upper GI cancer patients in South Australia. This study determined the patterns of care and outcomes for patients diagnosed with gastric and gastro-oesophageal junction (GOJ) cancers. Methods: Patients diagnosed with gastric cancer and GOJ (Siewert III) cancer between June 2012 and June 2016 were included. Patient demographics, cancer stage, histology, diagnostic modalities and treatment data was analysed from a prospective database. Stage-specific survival outcomes were determined and analysed for each treatment modality. Results: The study included 218 patients and at diagnosis 132 (61%) patients had stage I–III and 86 (39%) patients had stage IV disease. One hundred and ninety-five (89%) patients had gastric cancer and 23 (11%) had GOJ cancer (Siewert III). One hundred and nine (50%) patients underwent surgery, with 92% R0 resection rate. Forty-six patients received perioperative chemotherapy and 111 (51%) patients received palliative intent treatment. Median overall survival for stage II, III and IV cancers was 57.6 (95% CI 57.6-NR), 22.8 (95% CI 20.4–43.2), and 6.0 months (95% CI 4.8–8.4) respectively (p < 0.001). Median overall survival for patients who underwent perioperative chemotherapy and surgery was not reached as compared to 44.4 months (95% CI 28.8-NR) for patients who underwent surgery alone. Conclusion: Treatment outcomes for patients with gastric and GOJ cancer managed across South Australia met contemporary evidence-based practice. However, as most patients continue to present with late-stage disease, longer-term survival remains poor.

Original languageEnglish
Pages (from-to)2675-2682
Number of pages8
JournalANZ Journal of Surgery
Volume91
Issue number12
Early online date7 Oct 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • gastrointestinal cancer
  • multidisciplinary meeting
  • patterns of care
  • evidence-based care
  • evidence-based practice
  • Gastric cancer
  • gastro-oesophageal junction

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