Abstract
To the Editor,
Podocyte infolding glomerulopathy (PIG) is a rare histological finding in renal biopsies, first described in Japan in 2008. It is characterised by the infolding of podocytes into the glomerular basement membrane (GBM), leading to the formation of microspheres and/or microtubules within thickened GBM visualised on electron microscopy (EM).1 These cases have been commonly associated with autoimmune diseases with 70% having a history of systemic lupus erythematosus (SLE) or Sjögren's syndrome. They typically present with proteinuria, ranging from mild to nephrotic range, with or without haematuria, or with signs or symptoms of the systemic autoimmune disease...
Podocyte infolding glomerulopathy (PIG) is a rare histological finding in renal biopsies, first described in Japan in 2008. It is characterised by the infolding of podocytes into the glomerular basement membrane (GBM), leading to the formation of microspheres and/or microtubules within thickened GBM visualised on electron microscopy (EM).1 These cases have been commonly associated with autoimmune diseases with 70% having a history of systemic lupus erythematosus (SLE) or Sjögren's syndrome. They typically present with proteinuria, ranging from mild to nephrotic range, with or without haematuria, or with signs or symptoms of the systemic autoimmune disease...
Original language | English |
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Pages (from-to) | 886-890 |
Number of pages | 5 |
Journal | Pathology |
Volume | 55 |
Issue number | 6 |
Early online date | 6 Apr 2023 |
DOIs | |
Publication status | Published - Oct 2023 |
Keywords
- Podocyte infolding glomerulopathy (PIG)
- systemic lupus erythematosus (SLE)
- glomerular basement membrane (GBM)
- microspheres