Patterns of Symptom Reporting During Pregnancy Comparing Opioid Maintained and Control Women

Andrea Gordon, Olga Lopatko, Helen Stacey, Vicki Pearson, Anna Woods, Ann Fisk, Jason White

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    Abstract

    Objective: To characterize the range of symptoms experienced by pregnant methadone-maintained (MM) and buprenorphinemaintained (BM) women to determine whether these differ from those experienced by a control group of nonopioid exposed pregnant women. Opioid-maintained (OM) patients report high rates of symptoms related to direct opioid effects and withdrawal. Pregnancy is associated with a range of symptoms, some overlapping with opioid effects and withdrawal. Methods: Prospective, nonrandomized, open-label comparison study undertaken in a large teaching maternity hospital in South Australia. Pregnant BM(n=25),MM(n=25) and nonopioid exposed controls (n=25) were recruited and matched for age, parity, gravidity, alcohol consumption, and smoking status. Symptom report patterns, maternal withdrawal, and additional substance use were assessed. Results: MM women reported 10 and BM women reported 2 symptoms throughout pregnancy at rates greater than controls.Methadonemaintained women reported significantly (P < 0.05) more symptoms than BM women compared to controls throughout pregnancy. Methadone-maintained women reported 8 and BM women reported 3 symptoms in the third trimester at rates greater than controls. Methadone-maintained women reported greater opioid withdrawal than controls; this did not occur in BM women. Additional substance use was comparable between BM and MM women but greater than controls. Conclusions: Patterns of symptom reports may have clinical implications for maternal and fetal health during pregnancy for OM women including optimization of opioid dosing regimens, education regardingmaternal nutritional intake and preventing postnatal depression, thereby ensuring maternal health and fetal development during pregnancy and enhancing mother-infant bonding and healthy child development postnatally.

    Original languageEnglish
    Pages (from-to)258-264
    Number of pages7
    JournalJournal of Addiction Medicine
    Volume6
    Issue number4
    DOIs
    Publication statusPublished - 2012

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  • Cite this

    Gordon, A., Lopatko, O., Stacey, H., Pearson, V., Woods, A., Fisk, A., & White, J. (2012). Patterns of Symptom Reporting During Pregnancy Comparing Opioid Maintained and Control Women. Journal of Addiction Medicine, 6(4), 258-264. https://doi.org/10.1097/ADM.0b013e31826b299d