Pd(DPEPhos)Cl2-catalyzed Negishi cross-couplings for the formation of biaryl and diarylmethane phloroglucinol adducts

Eric Dennis, David Jeffery, Michael Perkins, Paul Smith

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Several functionalized biaryls and diarylmethanes containing the phloroglucinol subunit were synthesized in 55-85% yields using Negishi cross-couplings of 2,4,6-trimethoxyphenylzinc chloride with aryl and benzyl halides in the presence of catalytic quantities of Pd(DPEPhos)Cl2. These simple to prepare couplings were generally complete in 1-24 h depending on the halide, and were applicable to aryl and benzyl halides containing both electron-donating and electron-withdrawing groups.

    Original languageEnglish
    Pages (from-to)2125-2131
    Number of pages7
    JournalTetrahedron
    Volume67
    Issue number11
    DOIs
    Publication statusPublished - 18 Mar 2011

    Keywords

    • Biaryls
    • Catechin
    • Diarylmethanes
    • Negishi cross-coupling
    • Organozinc
    • Phloroglucinol

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