PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Nicole M. Smith; Colin L. Raston; Christopher B. Smith; Alexandre N. Sobolev

doi:10.1039/b700893g

PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Nicole M. Smith, Colin L. Raston, Christopher B. Smith, Alexandre N. Sobolev

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40 Citations (Scopus)

Abstract

The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

Original language	English
Pages (from-to)	1185-1190
Number of pages	6
Journal	Green Chemistry
Volume	9
Issue number	11
DOIs	https://doi.org/10.1039/b700893g
Publication status	Published - 7 Nov 2007
Externally published	Yes

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abstract = "The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.",

author = "Smith, {Nicole M.} and Raston, {Colin L.} and Smith, {Christopher B.} and Sobolev, {Alexandre N.}",

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AU - Sobolev, Alexandre N.

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AB - The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

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