TY - JOUR
T1 - PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines
AU - Smith, Nicole M.
AU - Raston, Colin L.
AU - Smith, Christopher B.
AU - Sobolev, Alexandre N.
PY - 2007/11/7
Y1 - 2007/11/7
N2 - The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.
AB - The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.
UR - http://www.scopus.com/inward/record.url?scp=35649002518&partnerID=8YFLogxK
U2 - 10.1039/b700893g
DO - 10.1039/b700893g
M3 - Article
AN - SCOPUS:35649002518
VL - 9
SP - 1185
EP - 1190
JO - Green Chemistry
JF - Green Chemistry
SN - 1463-9262
IS - 11
ER -