PEG mediated synthesis of amino-functionalised 2,4,6-triarylpyridines

Nicole M. Smith, Colin L. Raston, Christopher B. Smith, Alexandre N. Sobolev

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


The reaction of p-aminoacetophenone with aryl aldehydes in polyethylene glycol (PEG) in the presence of base, followed by treatment with ammonium acetate, affords 2,4,6-triarylpyridines in good yield as a 'one pot' procedure. The intermediate Claisen-Schmidt chalcone condensation products or the Michael addition 1,5-diketone products can be prepared in high yield, depending on the ratio of ketone to aldehyde, prior to treatment with ammonium acetate.

Original languageEnglish
Pages (from-to)1185-1190
Number of pages6
JournalGreen Chemistry
Issue number11
Publication statusPublished - 7 Nov 2007
Externally publishedYes


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