People with schizophrenia and depression have a low omega-3 index

Natalie Parletta; Dorota M. Zarnowiecki; Jihyun Cho; Amy L. Wilson; Nicholas Gerard Procter; Andrea L. Fielder; Svetlana Bogomolova; Kerin O. O'Dea; John Strachan; Matt Ballestrin; Andrew Champion; Barbara J. Meyer

doi:10.1016/j.plefa.2016.05.007

People with schizophrenia and depression have a low omega-3 index

Natalie Parletta, Dorota M. Zarnowiecki, Jihyun Cho, Amy L. Wilson, Nicholas Gerard Procter, Andrea L. Fielder, Svetlana Bogomolova, Kerin O. O'Dea, John Strachan, Matt Ballestrin, Andrew Champion, Barbara J. Meyer

College of Nursing and Health Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

Original language	English
Pages (from-to)	42-47
Number of pages	6
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	110
DOIs	https://doi.org/10.1016/j.plefa.2016.05.007
Publication status	Published - 1 Jul 2016

Keywords

Cardiovascular disease
Depression
Mental illness
Omega-3
Omega-3 index
Polyunsaturated fatty acids
Schizophrenia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.plefa.2016.05.007

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abstract = "Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.",

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AU - Parletta, Natalie

AU - Zarnowiecki, Dorota M.

AU - Cho, Jihyun

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AU - Procter, Nicholas Gerard

AU - Fielder, Andrea L.

AU - Bogomolova, Svetlana

AU - O'Dea, Kerin O.

AU - Strachan, John

AU - Ballestrin, Matt

AU - Champion, Andrew

AU - Meyer, Barbara J.

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AB - Cardiovascular disease (CVD) is higher in people with mental illness and is associated with a 30 year higher mortality rate in this population. Erythrocyte docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA) (omega-3 index)≤4% is a marker for increased mortality risk from CVD while >8% is protective. Omega-3 polyunsaturated fatty acids are also important for brain function and may ameliorate symptoms of mental illness. We investigated the erythrocyte omega-3 index in people with mental illness. One hundred and thirty adults aged 18-65 years (32.6% male) with schizophrenia (n=14) and depression (n=116) provided blood samples and completed physiological assessments and questionnaires. Both populations had risk factors for metabolic syndrome and CVD. The average omega-3 index was 3.95% (SD=1.06), compared to an estimated 5% in the Australian population. These data indicate an unfavourable omega-3 profile in people with mental illness that could contribute to higher CVD risk.

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People with schizophrenia and depression have a low omega-3 index

Abstract

Keywords

UN SDGs

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