Peripheral fields of sympathetic vasoconstrictor neurons in guinea pigs

Ian L. Gibbins, Beatrice Hoffmann, Judy L. Morris

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    We have combined retrograde axonal tracing using Fast Blue and Dil, with immunohistochemistry, to estimate the maximum size of peripheral fields of identified sympathetic vasoconstrictor neurons projecting to guinea-pig ear tips. Many neurons in the superior cervical ganglia were labelled with both Fast Blue and Dil after dye injections up to 7 mm apart. Few neurons were labelled when dye injections were 8-10 mm apart. Neurons labelled with both Dil and Fast Blue after dye injections 5-7 mm apart had, on average, larger somata (436 ± 84 μm2, mean ± SEM, n = 47) than neurons labelled with Dil only (388 ± 11 μm2, n = 147). Typically, 50-100 neurons innervated a region of vasculature 1 mm in diameter. We conclude that sympathetic vasoconstrictor neurons branch widely before converging on to their target blood vessels. Progressive recruitment of vasoconstrictor neurons with increasing field size would provide an efficient mechanism for graded neural control of the circulation.

    Original languageEnglish
    Pages (from-to)89-92
    Number of pages4
    JournalNeuroscience letters
    Volume248
    Issue number2
    DOIs
    Publication statusPublished - 29 May 1998

    Keywords

    • Guinea-pig
    • Immunohistochemistry
    • Neuropeptide Y
    • Retrograde axonal tracing
    • Vascular control

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