Persistence of Ebola Virus in Ocular Fluid during Convalescence

Jay Varkey; Jessica Shantha; Ian Crozier; Colleen Kraft; G Lyon; Aneesh Mehta; Gokul Kumar; Justine Smith; Markus Kainulainen; Shannon Whitmer; Ute Stroher; Timothy Uyeki; Bruce Ribner; Steven Yeh

doi:10.1056/NEJMoa1500306

Persistence of Ebola Virus in Ocular Fluid during Convalescence

Jay Varkey, Jessica Shantha, Ian Crozier, Colleen Kraft, G Lyon, Aneesh Mehta, Gokul Kumar, Justine Smith, Markus Kainulainen, Shannon Whitmer, Ute Stroher, Timothy Uyeki, Bruce Ribner, Steven Yeh

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335 Citations (Scopus)

Abstract

Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

Original language	English
Pages (from-to)	2423-2427
Number of pages	5
Journal	New England Journal of Medicine
Volume	372
Issue number	25
DOIs	https://doi.org/10.1056/NEJMoa1500306
Publication status	Published - 18 Jun 2015

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10.1056/NEJMoa1500306

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title = "Persistence of Ebola Virus in Ocular Fluid during Convalescence",

abstract = "Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.",

author = "Jay Varkey and Jessica Shantha and Ian Crozier and Colleen Kraft and G Lyon and Aneesh Mehta and Gokul Kumar and Justine Smith and Markus Kainulainen and Shannon Whitmer and Ute Stroher and Timothy Uyeki and Bruce Ribner and Steven Yeh",

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T1 - Persistence of Ebola Virus in Ocular Fluid during Convalescence

AU - Varkey, Jay

AU - Shantha, Jessica

AU - Crozier, Ian

AU - Kraft, Colleen

AU - Lyon, G

AU - Mehta, Aneesh

AU - Kumar, Gokul

AU - Smith, Justine

AU - Kainulainen, Markus

AU - Whitmer, Shannon

AU - Stroher, Ute

AU - Uyeki, Timothy

AU - Ribner, Bruce

AU - Yeh, Steven

PY - 2015/6/18

Y1 - 2015/6/18

N2 - Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

AB - Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

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U2 - 10.1056/NEJMoa1500306

DO - 10.1056/NEJMoa1500306

M3 - Article

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VL - 372

SP - 2423

EP - 2427

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 25

ER -

Persistence of Ebola Virus in Ocular Fluid during Convalescence

Abstract

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