Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes

Natalie Montarello; Alasdair Leslie; Rakchha Chhetri; Oisin Friel; Deepak Singhal; David Ross; David Yeung; Chung H. Kok; Peter J. Psaltis; Devendra K. Hiwase

doi:10.1182/bloodadvances.2022009173

Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes

Natalie Montarello, Alasdair Leslie, Rakchha Chhetri, Oisin Friel, Deepak Singhal, David Ross, David Yeung, Chung H. Kok, Peter J. Psaltis, Devendra K. Hiwase

Research output: Contribution to journal › Letter › peer-review

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Abstract

Cardiovascular events are the second most frequent cause of death in myelodysplastic syndromes(MDSs). 1-3 Furthermore, the management of acute coronary syndrome (ACS), which includes both type I and type II ACS, is more difficult in patients with MDS because of the increased risk of bleeding owing to thrombocytopenia and platelet dysfunction.4 Type I ACS includes type I myocardial infarction (MI),comprising ST-elevation MI and non–ST-elevation MI, and unstable angina; and type II ACS comprises type II MI owing to a mismatch between myocardial oxygen supply and demand.5 Currently, no guidelines exist for the appropriate management of ACS in MDS.

Original language	English
Pages (from-to)	3032-3035
Number of pages	4
Journal	Blood Advances
Volume	7
Issue number	13
DOIs	https://doi.org/10.1182/bloodadvances.2022009173
Publication status	Published - 11 Jul 2023
Externally published	Yes

Keywords

acute coronary syndrome
myelodysplastic syndromes
thrombocytopenia
platelet dysfunction
type I myocardial infarction
risk modeling

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1182/bloodadvances.2022009173Licence: CC BY-NC-ND

Published versionFinal published version, 353 KBLicence: CC BY-NC-ND

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title = "Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes",

abstract = "Cardiovascular events are the second most frequent cause of death in myelodysplastic syndromes(MDSs). 1-3 Furthermore, the management of acute coronary syndrome (ACS), which includes both type I and type II ACS, is more difficult in patients with MDS because of the increased risk of bleeding owing to thrombocytopenia and platelet dysfunction.4 Type I ACS includes type I myocardial infarction (MI),comprising ST-elevation MI and non–ST-elevation MI, and unstable angina; and type II ACS comprises type II MI owing to a mismatch between myocardial oxygen supply and demand.5 Currently, no guidelines exist for the appropriate management of ACS in MDS.",

keywords = "acute coronary syndrome, myelodysplastic syndromes, thrombocytopenia, platelet dysfunction, type I myocardial infarction, risk modeling",

author = "Natalie Montarello and Alasdair Leslie and Rakchha Chhetri and Oisin Friel and Deepak Singhal and David Ross and David Yeung and Kok, {Chung H.} and Psaltis, {Peter J.} and Hiwase, {Devendra K.}",

year = "2023",

month = jul,

day = "11",

doi = "10.1182/bloodadvances.2022009173",

language = "English",

volume = "7",

pages = "3032--3035",

journal = "Blood Advances",

issn = "2473-9529",

publisher = "Elsevier B.V.",

number = "13",

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TY - JOUR

T1 - Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes

AU - Montarello, Natalie

AU - Leslie, Alasdair

AU - Chhetri, Rakchha

AU - Friel, Oisin

AU - Singhal, Deepak

AU - Ross, David

AU - Yeung, David

AU - Kok, Chung H.

AU - Psaltis, Peter J.

AU - Hiwase, Devendra K.

PY - 2023/7/11

Y1 - 2023/7/11

N2 - Cardiovascular events are the second most frequent cause of death in myelodysplastic syndromes(MDSs). 1-3 Furthermore, the management of acute coronary syndrome (ACS), which includes both type I and type II ACS, is more difficult in patients with MDS because of the increased risk of bleeding owing to thrombocytopenia and platelet dysfunction.4 Type I ACS includes type I myocardial infarction (MI),comprising ST-elevation MI and non–ST-elevation MI, and unstable angina; and type II ACS comprises type II MI owing to a mismatch between myocardial oxygen supply and demand.5 Currently, no guidelines exist for the appropriate management of ACS in MDS.

AB - Cardiovascular events are the second most frequent cause of death in myelodysplastic syndromes(MDSs). 1-3 Furthermore, the management of acute coronary syndrome (ACS), which includes both type I and type II ACS, is more difficult in patients with MDS because of the increased risk of bleeding owing to thrombocytopenia and platelet dysfunction.4 Type I ACS includes type I myocardial infarction (MI),comprising ST-elevation MI and non–ST-elevation MI, and unstable angina; and type II ACS comprises type II MI owing to a mismatch between myocardial oxygen supply and demand.5 Currently, no guidelines exist for the appropriate management of ACS in MDS.

KW - acute coronary syndrome

KW - myelodysplastic syndromes

KW - thrombocytopenia

KW - platelet dysfunction

KW - type I myocardial infarction

KW - risk modeling

UR - http://www.scopus.com/inward/record.url?scp=85179470299&partnerID=8YFLogxK

U2 - 10.1182/bloodadvances.2022009173

DO - 10.1182/bloodadvances.2022009173

M3 - Letter

C2 - 36884290

AN - SCOPUS:85179470299

SN - 2473-9529

VL - 7

SP - 3032

EP - 3035

JO - Blood Advances

JF - Blood Advances

IS - 13

ER -

Personalized risk model for predicting risk of acute coronary syndrome in patients with myelodysplastic syndromes

Abstract

Keywords

UN SDGs

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