Pertussis toxin reduces the inhibitory action of morphine and ADP-ribosylates G proteins in guinea pig myenteric neurons

S. M. Johnson, C. M. Briton-Jones, T. M. Jeitner, M. Costa, M. F. Crouch

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    1 Citation (Scopus)

    Abstract

    Pretreatment with pertussis toxin reduced the inhibition of cholinergic transmission by morphine in the guinea pig ileum, and ADP-ribosylated Gi and Go proteins in myenteric neurons. The results suggest that μ receptors are coupled to Gi or Go.

    Original languageEnglish
    Title of host publicationNew leads in opioid research: Proceedings of the International Narcotics Research Conference. ICS914
    EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
    PublisherElsevier Science Publishers B.V., Amsterdam, Netherlands
    Pages299
    Number of pages1
    ISBN (Print)044481213X
    Publication statusPublished - 1990
    EventThe International Narcotics Research Conference -
    Duration: 8 Jul 198913 Jul 1989

    Publication series

    NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

    Conference

    ConferenceThe International Narcotics Research Conference
    Period8/07/8913/07/89

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  • Cite this

    Johnson, S. M., Briton-Jones, C. M., Jeitner, T. M., Costa, M., & Crouch, M. F. (1990). Pertussis toxin reduces the inhibitory action of morphine and ADP-ribosylates G proteins in guinea pig myenteric neurons. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: Proceedings of the International Narcotics Research Conference. ICS914 (pp. 299). (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V., Amsterdam, Netherlands.