Pharmacist-led multicomponent smoking cessation intervention in Victorian public hospitals: a randomised controlled trial

Dennis Thomas, Michael Abramson, Billie Bonevski, Simone Taylor, Susan G. Poole, Gregory R. Weeks, M Dooley, Eldho Paul, Johnson George

Research output: Contribution to journalArticlepeer-review


Aim: Smoking interventions initiated during hospitalisation are effective, but currently not widely available. Integrating cessation support into routine in-patient care may be beneficial. The efficacy of a pharmacist-led smoking cessation intervention was evaluated. Methods: A randomised controlled trial was carried out in three ‘smoke-free’ tertiary hospitals in Victoria. Usual care was compared with GIVE UP FORGOOD, an intervention comprising behavioural counselling and/or pharmacotherapy provided during hospital stay and on discharge with telephone follow-up 1 month post-discharge. Smoking status was assessed at baseline, discharge, 1, 6 and 12 months. The primary endpoint was carbon monoxide(CO) validated 7-day point prevalence abstinence at 6 months. Results: Participants (n = 600) had a mean (±SD) age 51 ± 14 years and64% were male. CO validated 7-day prevalent abstinence rates at 6-monthwere 12.9% and 13.6% in the intervention and usual care groups, respectively(adjusted odds ratio [OR] 1.01, 95% confidence interval [CI] 0.62–1.64). Self reported 7-day prevalent abstinence was significantly higher in the intervention group at both 1 (OR 1.57, CI 1.10–2.25) and 6 months (OR 1.60, CI 1.06–2.42), but not at 12 months. In a longitudinal analysis, self-reported 7-dayprevalent abstinence favoured the intervention (OR 1.52, CI 1.10–2.09). Pharmacotherapy usage was higher in the intervention group, both during hospital stay (52% vs 43%; P = 0.016) and at 6-month follow-up (57% vs 37%;P < 0.001). Low nicotine dependence, higher disease burden, higher motivation to quit, living in a family household and lack of depression were independent predictors of self-reported 7-day prevalent abstinence at 6-month.Conclusion: A hospital pharmacist-led smoking cessation intervention resulted in higher self-reported abstinence than usual care for 6 months after discharge but did not improve biochemically verified abstinence.
Original languageEnglish
Pages (from-to)61
Number of pages1
Issue numberS2
Publication statusPublished - Mar 2015
Externally publishedYes


  • : Smoking interventions
  • smoking cessation intervention
  • pharmacist


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