Abstract
A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. Plasma half lives of clonidine ranged from 6.9 to 9.4 h in five normotensive subjects. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.
| Original language | English |
|---|---|
| Pages (from-to) | 639-640 |
| Number of pages | 2 |
| Journal | Clinical Science and Molecular Medicine |
| Volume | 51 |
| Issue number | sup.3 |
| DOIs | |
| Publication status | Published - 1 Jan 1976 |
| Externally published | Yes |
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Davies, D. S., Wing, L. M. H., Reid, J. L., Tippett, P., & Dollery, C. T. (1976). Pharmacokinetic and pharmacological studies with clonidine in normal subjects. Clinical Science and Molecular Medicine, 51(sup.3), 639-640. https://doi.org/10.1042/cs051639s