Pharmacokinetic and pharmacological studies with clonidine in normal subjects

D. S. Davies; L. M.H. Wing; J. L. Reid; P Tippett; C. T. Dollery

doi:10.1042/cs051639s

Pharmacokinetic and pharmacological studies with clonidine in normal subjects

D. S. Davies, L. M.H. Wing, J. L. Reid, P Tippett, C. T. Dollery

Research output: Contribution to journal › Meeting Abstract › peer-review

8 Citations (Scopus)

Abstract

A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. Plasma half lives of clonidine ranged from 6.9 to 9.4 h in five normotensive subjects. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

Original language	English
Pages (from-to)	639-640
Number of pages	2
Journal	Clinical Science and Molecular Medicine
Volume	51
Issue number	sup.3
DOIs	https://doi.org/10.1042/cs051639s
Publication status	Published - 1 Jan 1976
Externally published	Yes

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title = "Pharmacokinetic and pharmacological studies with clonidine in normal subjects",

abstract = "A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. Plasma half lives of clonidine ranged from 6.9 to 9.4 h in five normotensive subjects. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.",

author = "Davies, {D. S.} and Wing, {L. M.H.} and Reid, {J. L.} and P Tippett and Dollery, {C. T.}",

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AU - Davies, D. S.

AU - Wing, L. M.H.

AU - Reid, J. L.

AU - Tippett, P

AU - Dollery, C. T.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. Plasma half lives of clonidine ranged from 6.9 to 9.4 h in five normotensive subjects. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

AB - A highly specific and sensitive assay based on stable isotope dilution and mass fragmentography has been developed to measure clonidine in plasma. Plasma half lives of clonidine ranged from 6.9 to 9.4 h in five normotensive subjects. Plasma clonidine concentration correlated with reduction in salivary flow and degree of sedation but not with change in blood pressure.

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U2 - 10.1042/cs051639s

DO - 10.1042/cs051639s

M3 - Meeting Abstract

C2 - 1071696

AN - SCOPUS:0017224784

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EP - 640

JO - Clinical Science and Molecular Medicine

JF - Clinical Science and Molecular Medicine

SN - 0301-0538

IS - sup.3

ER -

Pharmacokinetic and pharmacological studies with clonidine in normal subjects

Abstract

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