Pharmacokinetics of thiopental and pentobarbital enantiomers after intravenous administration of racemic thiopental

Khai T. Nguyen, Dianne P. Stephens, Michael J. McLeish, David P. Crankshaw, Denis J. Morgan

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26 Citations (Scopus)

Abstract

We studied the pharmacokinetics of thiopental enantiomers in 14 healthy patients aged 37-73 yr receiving racemic thiopental by intravenous (IV) bolus or IV infusion. Plasma concentration of each enantiomer was measured by chiral high-performance liquid chromatography. After IV bolus, the total plasma clearance (CL) (295 ± 132 mL/min) and volume of distribution at steady state (Vss) (139 ± 38.5 L) of R-thiopental were significantly greater than those of S-thiopental (230 ± 104 mL/min and 114 ± 47.5 L, respectively). The plasma unbound fraction (fu) was determined by ultrafiltration of plasma from six healthy volunteers. The fu of R-thiopental (12.4% ± 0.6%) was significantly greater than that of S-thiopental (10.0% ± 1.0%). When the CL and Vss of the two enantiomers were corrected for the difference in mean fu, there were no significant differences between enantiomers for these variables. As the 20%-30% difference between the enantiomers in total CL and total Vss could be accounted for by stereoselectivity in fu, these differences are not likely to be clinically significant. During 105-180 min IV infusion of racemic thiopental to the other patients, there was no difference between enantiomers in mean plasma concentrations of total or unbound thiopental or total pentobarbital, a major metabolite of thiopental (P > 0.05). Therefore, it is appropriate to relate pharmacodynamic effects to racemic plasma concentrations of thiopental during IV infusion of racemic thiopental.

Original languageEnglish
Pages (from-to)552-558
Number of pages7
JournalAnesthesia and analgesia
Volume83
Issue number3
DOIs
Publication statusPublished - Sep 1996
Externally publishedYes

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