Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice

Ranjay Chakraborty, Michael Bergen, Erica Landis, Duk Cheon Lee, P. Michael Iuvone, Machelle Pardue

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    Nitric oxide (NO), a gaseous neurotransmitter is synthesized in the mammalian retina and the choroid by activation of the enzyme nitric oxide synthase (NOS). Studies on chickens and guinea pigs have suggested that NO may mediate inhibition of axial eye growth through choroidal thickening. We hypothesize that pharmacological inhibition of NO will lead to myopic eye growth, thinner choroids and increased susceptibility to form-deprivation (FD) myopia in C57BL/6J wild-type mice.
    Original languageEnglish
    Number of pages1
    Publication statusPublished - Sept 2016
    EventARVO 2016 Annual Meeting - Seattle, United States
    Duration: 1 May 20165 May 2016


    ConferenceARVO 2016 Annual Meeting
    Abbreviated titleARVO 2016
    Country/TerritoryUnited States

    Bibliographical note

    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND


    • nitric oxide
    • retina
    • myopia
    • choroidal thickening


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