Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice

Ranjay Chakraborty; Michael Bergen; Erica Landis; Duk Cheon Lee; P. Michael Iuvone; Machelle Pardue

Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice

Ranjay Chakraborty, Michael Bergen, Erica Landis, Duk Cheon Lee, P. Michael Iuvone, Machelle Pardue

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Abstract

Nitric oxide (NO), a gaseous neurotransmitter is synthesized in the mammalian retina and the choroid by activation of the enzyme nitric oxide synthase (NOS). Studies on chickens and guinea pigs have suggested that NO may mediate inhibition of axial eye growth through choroidal thickening. We hypothesize that pharmacological inhibition of NO will lead to myopic eye growth, thinner choroids and increased susceptibility to form-deprivation (FD) myopia in C57BL/6J wild-type mice.

Original language	English
Number of pages	1
Publication status	Published - Sept 2016
Event	ARVO 2016 Annual Meeting - Seattle, United States Duration: 1 May 2016 → 5 May 2016

Conference

Conference	ARVO 2016 Annual Meeting
Abbreviated title	ARVO 2016
Country/Territory	United States
City	Seattle
Period	1/05/16 → 5/05/16

Bibliographical note

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

Keywords

nitric oxide
retina
myopia
choroidal thickening

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https://iovs.arvojournals.org/article.aspx?articleid=2562881&resultClick=1Licence: CC BY-NC-ND

Cite this

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title = "Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice",

abstract = "Nitric oxide (NO), a gaseous neurotransmitter is synthesized in the mammalian retina and the choroid by activation of the enzyme nitric oxide synthase (NOS). Studies on chickens and guinea pigs have suggested that NO may mediate inhibition of axial eye growth through choroidal thickening. We hypothesize that pharmacological inhibition of NO will lead to myopic eye growth, thinner choroids and increased susceptibility to form-deprivation (FD) myopia in C57BL/6J wild-type mice.",

keywords = "nitric oxide, retina, myopia, choroidal thickening",

author = "Ranjay Chakraborty and Michael Bergen and Erica Landis and Lee, {Duk Cheon} and Iuvone, {P. Michael} and Machelle Pardue",

note = "This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND; ARVO 2016 Annual Meeting, ARVO 2016 ; Conference date: 01-05-2016 Through 05-05-2016",

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TY - CONF

T1 - Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice

AU - Chakraborty, Ranjay

AU - Bergen, Michael

AU - Landis, Erica

AU - Lee, Duk Cheon

AU - Iuvone, P. Michael

AU - Pardue, Machelle

N1 - This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. CC BY-NC-ND

PY - 2016/9

Y1 - 2016/9

N2 - Nitric oxide (NO), a gaseous neurotransmitter is synthesized in the mammalian retina and the choroid by activation of the enzyme nitric oxide synthase (NOS). Studies on chickens and guinea pigs have suggested that NO may mediate inhibition of axial eye growth through choroidal thickening. We hypothesize that pharmacological inhibition of NO will lead to myopic eye growth, thinner choroids and increased susceptibility to form-deprivation (FD) myopia in C57BL/6J wild-type mice.

AB - Nitric oxide (NO), a gaseous neurotransmitter is synthesized in the mammalian retina and the choroid by activation of the enzyme nitric oxide synthase (NOS). Studies on chickens and guinea pigs have suggested that NO may mediate inhibition of axial eye growth through choroidal thickening. We hypothesize that pharmacological inhibition of NO will lead to myopic eye growth, thinner choroids and increased susceptibility to form-deprivation (FD) myopia in C57BL/6J wild-type mice.

KW - nitric oxide

KW - retina

KW - myopia

KW - choroidal thickening

M3 - Abstract

T2 - ARVO 2016 Annual Meeting

Y2 - 1 May 2016 through 5 May 2016

ER -

Pharmacological inhibition of nitric oxide increases myopia susceptibility in mice

Abstract

Conference

Bibliographical note

Keywords

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