Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

László Pajor; András Matolcsy; János A. Vass; Gábor Méhes; Éva Marton; Ferenc Szabó; János L. Iványi

doi:10.1016/S0145-2126(97)00131-8

Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

László Pajor, András Matolcsy, János A. Vass, Gábor Méhes, Éva Marton, Ferenc Szabó, János L. Iványi

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14 Citations (Scopus)

Abstract

The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.

Original language	English
Pages (from-to)	13-17
Number of pages	5
Journal	Leukemia Research
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/S0145-2126(97)00131-8
Publication status	Published - Jan 1998
Externally published	Yes

Keywords

Acute lymphoblastic leukemia
Immunoglobulin gene rearrangement
Myelodysplastic syndrome

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title = "Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome",

abstract = "The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.",

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T1 - Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

AU - Pajor, László

AU - Matolcsy, András

AU - Vass, János A.

AU - Méhes, Gábor

AU - Marton, Éva

AU - Szabó, Ferenc

AU - Iványi, János L.

PY - 1998/1

Y1 - 1998/1

N2 - The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.

AB - The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.

KW - Acute lymphoblastic leukemia

KW - Immunoglobulin gene rearrangement

KW - Myelodysplastic syndrome

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JF - Leukemia Research

IS - 1

ER -

Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

Abstract

Keywords

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