Phenotypic and genotypic analyses of blastic cell population suggest that pure B-lymphoblastic leukemia may arise from myelodysplastic syndrome

László Pajor, András Matolcsy, János A. Vass, Gábor Méhes, Éva Marton, Ferenc Szabó, János L. Iványi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The case history of a 70-year-old man with myelodysplastic syndrome terminated into acute leukemia in 22 months is presented. The leukemic cells exhibited multifocal acid phosphatase positivity and expressed TdT, CD45, CD34 and HLA-DR but not myeloid, monocytic or megakaryocytic differentiation antigenes. The genotypic analysis revealed clonal immunoglobulin heavy chain gene rearrangement. These phenotypic and genotypic analyses of the blastic cell population suggest that myelodysplastic syndrome may transform to pure acute lymphoblastic leukemia of B-cell origin.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalLeukemia Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1998
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Immunoglobulin gene rearrangement
  • Myelodysplastic syndrome

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