Phosphofructokinase activity in fibroblasts from patients with Alzheimer's disease and age- and sex-matched controls

Neil R. Sims, John P. Blass

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The activity of the enzyme phosphofructokinase (PFK) was comparable in cultured skin fibroblasts from eight patients with Alzheimer's disease and eight age- and sex-matched controls. Mean activities were similar in the two groups whether measured under nonallosteric conditions at pH 8.0 or under allosteric conditions at pH 7.0, in the presence of 0.1 or 1 mM ATP. Activities of PFK in Alzheimer's disease and control cells also showed a similar temperature dependence and similar isozyme patterns on column chromatography. These results argue against the existence of significant structural variations of PFK in Alzheimer's disease.

Original languageEnglish
Pages (from-to)83-90
Number of pages8
JournalMetabolic Brain Disease
Volume1
DOIs
Publication statusPublished - Mar 1986
Externally publishedYes

Keywords

  • Alzheimer's disease
  • fibroblasts
  • phosphofructokinase

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