Phosphofructokinase activity in the brain in Alzheimer's disease

Neil R. Sims; John P. Blass; Cathleen Murphy; David M. Bowen; David Neary

doi:10.1002/ana.410210517

Phosphofructokinase activity in the brain in Alzheimer's disease

Neil R. Sims, John P. Blass, Cathleen Murphy, David M. Bowen, David Neary

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Abstract

The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.

Original language	English
Pages (from-to)	509-510
Number of pages	2
Journal	Annals of Neurology
Volume	21
Issue number	5
DOIs	https://doi.org/10.1002/ana.410210517
Publication status	Published - May 1987
Externally published	Yes

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title = "Phosphofructokinase activity in the brain in Alzheimer's disease",

abstract = "The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.",

author = "Sims, {Neil R.} and Blass, {John P.} and Cathleen Murphy and Bowen, {David M.} and David Neary",

year = "1987",

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AU - Sims, Neil R.

AU - Blass, John P.

AU - Murphy, Cathleen

AU - Bowen, David M.

AU - Neary, David

PY - 1987/5

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N2 - The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.

AB - The activity of phosphofructokinase, a key regulatory enzyme of glycolysis, was determined in neurosurgical samples of neocortex obtained from 6 patients with primary degenerative dementia, including 4 with Alzheimer's disease. No consistent reductions were seen compared with samples from nondemented controls. These results contrast with the greatly reduced activity reported previously for postmortem brain specimens from patients with Alzheimer's disease.

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DO - 10.1002/ana.410210517

M3 - Article

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VL - 21

SP - 509

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JO - Annals of Neurology

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Phosphofructokinase activity in the brain in Alzheimer's disease

Abstract

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