TY - JOUR
T1 - Phosphoinositide-derived second messengers and the regulation of Ca2+ in vascular smooth muscle
AU - Nahorski, S. R.
AU - Wilcox, R. A.
AU - Mackrill, J. J.
AU - Challiss, R. A.J.
PY - 1994/12
Y1 - 1994/12
N2 - Vascular smooth muscle and the phosphoinositide signalling pathway: Vascular smooth muscle tone can be regulated by an array of agonists which act via receptor-mediated transmembrane signalling pathways to modify the concentrations of key intracellular second messengers. Following agonist stimulation the phosphoinositide signalling pathway initiates the contraction process in vascular smooth muscle, via the second messengers myo-inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol. Diversity of calcium-regulatory mechanisms: The vascular smooth muscle cell apparently sustains the contraction with a number of diverse mechanisms, which act to increase intracellular Ca2+ by regulating both Ca2+ influx across the plasma membrane and Ca2+ release from intracellular calcium stores, or may act in the apparent absence of elevated cytosolic Ca2+ concentrations. Future research: The exact nature of these physiological interactions and their exact function are not yet fully understood. In particular, identification of the natural role of specific phospholipase C(δ), phospholipase C(γ) and protein kinase C isozymes and also the various ryanodine and myo-inositol 1,4,5-trisphosphate receptor subtypes present in vascular smooth muscle will prove critical to future understanding of the regulation of vascular smooth muscle tone in both the normal and the hypertensive phenotype.
AB - Vascular smooth muscle and the phosphoinositide signalling pathway: Vascular smooth muscle tone can be regulated by an array of agonists which act via receptor-mediated transmembrane signalling pathways to modify the concentrations of key intracellular second messengers. Following agonist stimulation the phosphoinositide signalling pathway initiates the contraction process in vascular smooth muscle, via the second messengers myo-inositol 1,4,5-trisphosphate and sn-1,2-diacylglycerol. Diversity of calcium-regulatory mechanisms: The vascular smooth muscle cell apparently sustains the contraction with a number of diverse mechanisms, which act to increase intracellular Ca2+ by regulating both Ca2+ influx across the plasma membrane and Ca2+ release from intracellular calcium stores, or may act in the apparent absence of elevated cytosolic Ca2+ concentrations. Future research: The exact nature of these physiological interactions and their exact function are not yet fully understood. In particular, identification of the natural role of specific phospholipase C(δ), phospholipase C(γ) and protein kinase C isozymes and also the various ryanodine and myo-inositol 1,4,5-trisphosphate receptor subtypes present in vascular smooth muscle will prove critical to future understanding of the regulation of vascular smooth muscle tone in both the normal and the hypertensive phenotype.
KW - Calcium mobilization
KW - Endothelial cells
KW - Inositol 1,4,5-trisphosphate
KW - Inositol 1,4,5-trisphosphate receptors
KW - Phosphatidylinositol 4,5-bisphosphate
KW - Ryanodine receptors
KW - Vascular smooth muscle
UR - http://www.scopus.com/inward/record.url?scp=0028651979&partnerID=8YFLogxK
UR - https://pubmed.ncbi.nlm.nih.gov/7769483/
M3 - Article
C2 - 7769483
AN - SCOPUS:0028651979
VL - 12
SP - S133-S143
JO - Journal of hypertension. Supplement : official journal of the International Society of Hypertension
JF - Journal of hypertension. Supplement : official journal of the International Society of Hypertension
SN - 0952-1178
IS - 10
ER -