Physical inactivity is associated with moderate-severe obstructive sleep apnea

Laila Simpson, Nigel McArdle, Peter R. Eastwood, Kim L. Ward, Matthew N. Cooper, Annette C. Wilson, David R. Hillman, Lyle J. Palmer, Sutapa Mukherjee

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    Abstract

    Study Objectives: To investigate whether low levels of physical activity were associated with an increased occurrence of obstructive sleep apnea (OSA), OSA-related symptoms, and cardiometabolic risk. Methods: A case-control study design was used. OSA cases were patients referred to a sleep clinic for suspected OSA (n = 2,340). Controls comprised participants from the Busselton community (n = 1,931). Exercise and occupational activity were derived from questionnaire data. Associations were modelled using logistic and linear regression and adjusted for confounders. Results: In comparison with moderate exercise, the high, low, and nil exercise groups had an odds ratio (OR) for moderate-severe OSA of 0.6 (95% CI 0.5-0.8), 1.6 (95% CI 1.2-2.0), and 2.7 (95% CI 1.9-3.7), respectively. Relative to men in heavy activity occupations, men in medium, light and sedentary occupations had an OR for moderate-severe OSA of 1.7 (95% CI 1.1-2.5), 2.1 (95% CI 1.4-3.2), and 1.8 (95% CI 1.2-2.8), respectively. Relative to women in medium activity occupations, women in light and sedentary occupations had an OR for moderate-severe OSA of 4.2 (95% CI 2.6-7.2) and 3.5 (2.0-6.0). OSA patients who adequately exercised had lower: levels of doctor-diagnosed depression (p = 0.047); symptoms of fatigue (p < 0.0001); systolic (p = 0.015) and diastolic blood pressure (p = 0.015); and C-reactive protein (CRP) (p = 0.003). Conclusions: Low levels of physical activity were associated with moderate-severe OSA. Exercise in individuals with OSA is associated with lower levels of depression, fatigue, blood pressure and CRP.

    Original languageEnglish
    Pages (from-to)1091-1099A
    JournalJournal of Clinical Sleep Medicine
    Volume11
    Issue number10
    DOIs
    Publication statusPublished - 1 Jan 2015

    Keywords

    • Cardio metabolic
    • Exercise
    • Occupation
    • Sleep disordered breathing
    • Weight

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  • Cite this

    Simpson, L., McArdle, N., Eastwood, P. R., Ward, K. L., Cooper, M. N., Wilson, A. C., Hillman, D. R., Palmer, L. J., & Mukherjee, S. (2015). Physical inactivity is associated with moderate-severe obstructive sleep apnea. Journal of Clinical Sleep Medicine, 11(10), 1091-1099A. https://doi.org/10.5664/jcsm.5078