Physiological phenotypes

Danny Joel Eckert, Andrew Wellman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

6 Citations (Scopus)

Abstract

OSA is a multifactorial disorder with several physiological phenotypes. Pharyngeal anatomy/collapsibility is the primary abnormality in most OSA patients. However, the extent of UA anatomical compromise varies widely between OSA patients. Many have only a modest degree of anatomical impairment. Accordingly, a number of other non-anatomical contributors also play a role. These include an oversensitive ventilatory control system, a low respiratory arousal threshold, and poor pharyngeal muscle responsiveness or effectiveness during sleep. The contribution of these non-anatomical factors has only recently been recognised. This chapter reviews the data establishing the importance of these variables and describes a graphic, physiological model integrating them to illustrate their relative contribution. Ultimately, such a model could be useful for guiding therapy and advancing the field of OSA management beyond the “one size fits all” approach of CPAP.
Original languageEnglish
Title of host publicationObstructive Sleep Apnoea
Subtitle of host publicationERS Monograph 67
EditorsFerran Barbe, Jean-Louis Pepin
Place of PublicationSheffield UK
PublisherEuropean Respiratory Society
Chapter2
Pages9-23
Number of pages15
Volume67
Edition9781849840606
ISBN (Electronic)9781849840606
ISBN (Print)9781849840590
DOIs
Publication statusPublished - Mar 2015
Externally publishedYes

Publication series

NameERS Monographs
PublisherERS Publications
Number67
ISSN (Print)2312-508X
ISSN (Electronic)2312-5098

Keywords

  • obstructive sleep apnea
  • anatomy
  • muscle response

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