Abstract
The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates the flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure, it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause of adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiologic changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”
Original language | English |
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Title of host publication | The Pancreas |
Subtitle of host publication | An Integrated Textbook of Basic Science, Medicine, and Surgery |
Editors | Hans G. Beger, Andrew L. Warshaw, Ralph H. Hruban, Markus W. Buchler, Markus M. Lerch, John P. Neoptolemos, Tooru Shimosegawa, David C. Whitcomb |
Place of Publication | Hoboken, New Jersey |
Publisher | John Wiley & Sons, Inc |
Chapter | 7 |
Pages | 75-83 |
Number of pages | 9 |
Edition | 3 |
ISBN (Electronic) | 9781119188414 |
ISBN (Print) | 9781119188391 |
DOIs | |
Publication status | Published - 2018 |
Keywords
- Sphincter of Oddi
- Physiology
- Pathophysiology