Physiology and Pathophysiology of Function of Sphincter of Oddi

Savio George Barreto; James Toouli

doi:10.1002/9781119188421.ch7

Physiology and Pathophysiology of Function of Sphincter of Oddi

Savio George Barreto, James Toouli

College of Medicine and Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates the flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure, it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause of adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiologic changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”

Original language	English
Title of host publication	The Pancreas
Subtitle of host publication	An Integrated Textbook of Basic Science, Medicine, and Surgery
Editors	Hans G. Beger, Andrew L. Warshaw, Ralph H. Hruban, Markus W. Buchler, Markus M. Lerch, John P. Neoptolemos, Tooru Shimosegawa, David C. Whitcomb
Place of Publication	Hoboken, New Jersey
Publisher	John Wiley & Sons
Chapter	7
Pages	75-83
Number of pages	9
Edition	3
ISBN (Electronic)	9781119188414
ISBN (Print)	9781119188391
DOIs	https://doi.org/10.1002/9781119188421.ch7
Publication status	Published - 2018

Keywords

Sphincter of Oddi
Physiology
Pathophysiology

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Barreto, S. G., & Toouli, J. (2018). Physiology and Pathophysiology of Function of Sphincter of Oddi. In H. G. Beger, A. L. Warshaw, R. H. Hruban, M. W. Buchler, M. M. Lerch, J. P. Neoptolemos, T. Shimosegawa, & D. C. Whitcomb (Eds.), The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery (3 ed., pp. 75-83). John Wiley & Sons. https://doi.org/10.1002/9781119188421.ch7

Barreto, Savio George ; Toouli, James. / Physiology and Pathophysiology of Function of Sphincter of Oddi. The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery. editor / Hans G. Beger ; Andrew L. Warshaw ; Ralph H. Hruban ; Markus W. Buchler ; Markus M. Lerch ; John P. Neoptolemos ; Tooru Shimosegawa ; David C. Whitcomb. 3. ed. Hoboken, New Jersey : John Wiley & Sons, 2018. pp. 75-83

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abstract = "The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates the flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure, it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause of adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiologic changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”",

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Barreto, SG & Toouli, J 2018, Physiology and Pathophysiology of Function of Sphincter of Oddi. in HG Beger, AL Warshaw, RH Hruban, MW Buchler, MM Lerch, JP Neoptolemos, T Shimosegawa & DC Whitcomb (eds), The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery. 3 edn, John Wiley & Sons, Hoboken, New Jersey, pp. 75-83. https://doi.org/10.1002/9781119188421.ch7

Physiology and Pathophysiology of Function of Sphincter of Oddi. / Barreto, Savio George ; Toouli, James.

The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery. ed. / Hans G. Beger; Andrew L. Warshaw; Ralph H. Hruban; Markus W. Buchler; Markus M. Lerch; John P. Neoptolemos; Tooru Shimosegawa; David C. Whitcomb. 3. ed. Hoboken, New Jersey : John Wiley & Sons, 2018. p. 75-83.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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N2 - The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates the flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure, it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause of adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiologic changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”

AB - The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates the flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure, it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause of adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiologic changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”

KW - Sphincter of Oddi

KW - Physiology

KW - Pathophysiology

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DO - 10.1002/9781119188421.ch7

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BT - The Pancreas

A2 - Beger, Hans G.

A2 - Warshaw, Andrew L.

A2 - Hruban, Ralph H.

A2 - Buchler, Markus W.

A2 - Lerch, Markus M.

A2 - Neoptolemos, John P.

A2 - Shimosegawa, Tooru

A2 - Whitcomb, David C.

PB - John Wiley & Sons

CY - Hoboken, New Jersey

ER -

Barreto SG , Toouli J. Physiology and Pathophysiology of Function of Sphincter of Oddi. In Beger HG, Warshaw AL, Hruban RH, Buchler MW, Lerch MM, Neoptolemos JP, Shimosegawa T, Whitcomb DC, editors, The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery. 3 ed. Hoboken, New Jersey: John Wiley & Sons. 2018. p. 75-83 https://doi.org/10.1002/9781119188421.ch7

Physiology and Pathophysiology of Function of Sphincter of Oddi

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