Physiology and Pathophysiology of Function of Sphincter of Oddi

Savio George Barreto; James Toouli

doi:10.1002/9781119876007.ch6

Physiology and Pathophysiology of Function of Sphincter of Oddi

Savio George Barreto, James Toouli

College of Medicine and Public Health

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause for adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiological changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”

Original language	English
Title of host publication	The Pancreas
Subtitle of host publication	an Integrated Textbook of Basic Science, Medicine, and Surgery
Editors	Hans G. Beger, Markus W. Büchler, Ralph H. Hruban, Julia Mayerle, John P. Neoptolemos, Tooru Shimosegawa , Andrew L. Warshaw, David C. Whitcomb, Yupei Zhao, Christiane Groß
Place of Publication	Hoboken, NJ
Publisher	Wiley
Chapter	6
Pages	56-64
Number of pages	9
Edition	4th
ISBN (Electronic)	9781119876007, 9781119875994
ISBN (Print)	9781119875970
DOIs	https://doi.org/10.1002/9781119876007.ch6
Publication status	Published - 2023

Keywords

sphincter of Oddi
Bile duct
neuronal modulators
hormonal modulators
acute pancreatitis
sphincter of Oddi dysfunction

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10.1002/9781119876007.ch6Licence: In Copyright

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Barreto, S. G., & Toouli, J. (2023). Physiology and Pathophysiology of Function of Sphincter of Oddi. In H. G. Beger, M. W. Büchler, R. H. Hruban, J. Mayerle, J. P. Neoptolemos, T. Shimosegawa , A. L. Warshaw, D. C. Whitcomb, Y. Zhao, & C. Groß (Eds.), The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery (4th ed., pp. 56-64). Wiley. https://doi.org/10.1002/9781119876007.ch6

Barreto, Savio George ; Toouli, James. / Physiology and Pathophysiology of Function of Sphincter of Oddi. The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery. editor / Hans G. Beger ; Markus W. Büchler ; Ralph H. Hruban ; Julia Mayerle ; John P. Neoptolemos ; Tooru Shimosegawa ; Andrew L. Warshaw ; David C. Whitcomb ; Yupei Zhao ; Christiane Groß. 4th. ed. Hoboken, NJ : Wiley, 2023. pp. 56-64

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abstract = "The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause for adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiological changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”",

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author = "Barreto, {Savio George} and James Toouli",

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booktitle = "The Pancreas",

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Barreto, SG & Toouli, J 2023, Physiology and Pathophysiology of Function of Sphincter of Oddi. in HG Beger, MW Büchler, RH Hruban, J Mayerle, JP Neoptolemos, T Shimosegawa , AL Warshaw, DC Whitcomb, Y Zhao & C Groß (eds), The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery. 4th edn, Wiley, Hoboken, NJ, pp. 56-64. https://doi.org/10.1002/9781119876007.ch6

Physiology and Pathophysiology of Function of Sphincter of Oddi. / Barreto, Savio George ; Toouli, James.
The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery. ed. / Hans G. Beger; Markus W. Büchler; Ralph H. Hruban; Julia Mayerle; John P. Neoptolemos; Tooru Shimosegawa ; Andrew L. Warshaw; David C. Whitcomb; Yupei Zhao; Christiane Groß. 4th. ed. Hoboken, NJ: Wiley, 2023. p. 56-64.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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AB - The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause for adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiological changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”

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PB - Wiley

CY - Hoboken, NJ

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Physiology and Pathophysiology of Function of Sphincter of Oddi

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