Physiology and Pathophysiology of Function of Sphincter of Oddi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The sphincter of Oddi is a small but important muscle complex located at the lower end of the common bile duct that modulates flow of bile and pancreatic juice across one of the busiest anatomic junctions of the body. Its activity is controlled by an interaction of neuronal and hormonal modulators. In such a complex structure it is not surprising that at times disorders in motility arise and these disorders lead to significant clinical syndromes such as biliary pain (pre- and post-cholecystectomy) and recurrent acute pancreatitis. It has also been postulated to be a cause for adult choledochal cysts. This chapter provides a detailed insight into the physiology of the sphincter of Oddi and the pathophysiological changes that accompany the syndrome collectively known as “sphincter of Oddi dysfunction.”
Original languageEnglish
Title of host publicationThe Pancreas
Subtitle of host publicationan Integrated Textbook of Basic Science, Medicine, and Surgery
EditorsHans G. Beger, Markus W. Büchler, Ralph H. Hruban, Julia Mayerle, John P. Neoptolemos, Tooru Shimosegawa , Andrew L. Warshaw, David C. Whitcomb, Yupei Zhao, Christiane Groß
Place of PublicationHoboken, NJ
Number of pages9
ISBN (Electronic)9781119876007, 9781119875994
ISBN (Print)9781119875970
Publication statusPublished - 2023


  • sphincter of Oddi
  • Bile duct
  • neuronal modulators
  • hormonal modulators
  • acute pancreatitis
  • sphincter of Oddi dysfunction


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