Picrotoxin-, kainic acid- and seizure-induced Fos in brainstem, with special reference to catecholamine cell groups

John O. Willoughby, Lorraine MacKenzie

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    One of the original views about motor convulsions with bilateral synchronous EEG discharges was that ascending projections from deep midline brainstem neurons subserve discharge synchronisation. We examined this in kainic acid- and picrotoxin-induced seizures using the distribution of Fos protein expression in the brainstem as a possible marker of brainstem neuronal activation. Before seizure, Fos was present in parabrachial nucleus, central grey and A1/C1 cell groups and, to a lesser extent, in A2/C2 cell groups and A6 neurons. Seizure correlated with further induction of Fos in these cell groups as well as in A6 neurons. There was no Fos in other cell groups with bilateral cerebro-cortical projections nor in cell groups likely to participate in the expression of seizures, reflecting a limitation of the Fos method. This study provides evidence of locus Coeruleus involvement in these two models of seizure.

    Original languageEnglish
    Pages (from-to)163-169
    Number of pages7
    JournalNeuroscience Research
    Volume33
    Issue number3
    DOIs
    Publication statusPublished - Mar 1999

    Keywords

    • Brainstem
    • Fos
    • Kainic acid
    • Locus coeruleus
    • Picrotoxin
    • Seizures
    • Tyrosine hydroxylase

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