Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health

Ifene David Festus; Jeri Spilberg; Martin E. Young; Sean Cain; Sepideh Khoshnevis; Michael H. Smolensky; Fariya Zaheer; Giannina Descalzi; Tami A. Martino

doi:10.1016/j.tem.2024.02.011

Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health

Ifene David Festus, Jeri Spilberg, Martin E. Young, Sean Cain, Sepideh Khoshnevis, Michael H. Smolensky, Fariya Zaheer, Giannina Descalzi, Tami A. Martino

Research output: Contribution to journal › Review article › peer-review

14 Citations (Scopus)

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Abstract

Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.

Original language	English
Pages (from-to)	607-623
Number of pages	17
Journal	Trends in Endocrinology and Metabolism
Volume	35
Issue number	7
DOIs	https://doi.org/10.1016/j.tem.2024.02.011
Publication status	Published - Jul 2024
Externally published	Yes

Keywords

cardiovascular disease
chronotherapy
circadian biology
feeding/fasting
heart clock
hypertension
light
rest

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tem.2024.02.011Licence: CC BY-NC-ND

Final published versionFinal published version, 1.88 MBLicence: CC BY-NC-ND

Cite this

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title = "Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health",

abstract = "Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.",

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author = "Festus, {Ifene David} and Jeri Spilberg and Young, {Martin E.} and Sean Cain and Sepideh Khoshnevis and Smolensky, {Michael H.} and Fariya Zaheer and Giannina Descalzi and Martino, {Tami A.}",

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AU - Festus, Ifene David

AU - Spilberg, Jeri

AU - Young, Martin E.

AU - Cain, Sean

AU - Khoshnevis, Sepideh

AU - Smolensky, Michael H.

AU - Zaheer, Fariya

AU - Descalzi, Giannina

AU - Martino, Tami A.

PY - 2024/7

Y1 - 2024/7

N2 - Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.

AB - Cardiovascular disease (CVD) is a global health concern. Circadian medicine improves cardiovascular care by aligning treatments with our body's daily rhythms and their underlying cellular circadian mechanisms. Time-based therapies, or chronotherapies, show special promise in clinical cardiology. They optimize treatment schedules for better outcomes with fewer side effects by recognizing the profound influence of rhythmic body cycles. In this review, we focus on three chronotherapy areas (medication, light, and meal timing) with potential to enhance cardiovascular care. We also highlight pioneering research in the new field of rest, the gut microbiome, novel chronotherapies for hypertension, pain management, and small molecules that targeting the circadian mechanism.

KW - cardiovascular disease

KW - chronotherapy

KW - circadian biology

KW - feeding/fasting

KW - heart clock

KW - hypertension

KW - light

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Pioneering new frontiers in circadian medicine chronotherapies for cardiovascular health

Abstract

Keywords

UN SDGs

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