Placental adaptations in growth restriction

Song Zhang, Timothy R.H. Regnault, Paige L. Barker, Kimberley J. Botting, Isabella C. McMillen, Christine M. McMillan, Claire T. Roberts, Janna L. Morrison

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

The placenta is the primary interface between the fetus and mother and plays an important role in maintaining fetal development and growth by facilitating the transfer of substrates and participating in modulating the maternal immune response to prevent immunological rejection of the conceptus. The major substrates required for fetal growth include oxygen, glucose, amino acids and fatty acids, and their transport processes depend on morphological characteristics of the placenta, such as placental size, morphology, blood flow and vascularity. Other factors including insulin-like growth factors, apoptosis, autophagy and glucocorticoid exposure also affect placental growth and substrate transport capacity. Intrauterine growth restriction (IUGR) is often a consequence of insufficiency, and is associated with a high incidence of perinatal morbidity and mortality, as well as increased risk of cardiovascular and metabolic diseases in later life. Several different experimental methods have been used to induce placental insufficiency and IUGR in animal models and a range of factors that regulate placental growth and substrate transport capacity have been demonstrated. While no model system completely recapitulates human IUGR, these animal models allow us to carefully dissect cellular and molecular mechanisms to improve our understanding and facilitate development of therapeutic interventions.

Original languageEnglish
Pages (from-to)360-389
Number of pages30
JournalNutrients
Volume7
Issue number1
DOIs
Publication statusPublished - 8 Jan 2015
Externally publishedYes

Bibliographical note

© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • IUGR
  • Placental morphology
  • Substrate transport
  • Vascularity

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  • Cite this

    Zhang, S., Regnault, T. R. H., Barker, P. L., Botting, K. J., McMillen, I. C., McMillan, C. M., Roberts, C. T., & Morrison, J. L. (2015). Placental adaptations in growth restriction. Nutrients, 7(1), 360-389. https://doi.org/10.3390/nu7010360