TY - JOUR
T1 - Plasma atrial natriuretic peptide in patients with acute myocardial infarction
T2 - Effects of streptokinase
AU - Phillips, P. A.
AU - Sasadeus, J.
AU - Hodsman, G. P.
AU - Horowitz, J.
AU - Saltups, A.
AU - Johnston, C. I.
PY - 1989
Y1 - 1989
N2 - Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM)) were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
AB - Plasma concentrations of immunoreactive atrial natriuretic peptide (mean (SEM)) were measured in 135 patients admitted to two coronary care units with myocardial infarction, ischaemic chest pain, or non-ischaemic chest pain. Concentrations were significantly higher in patients with acute myocardial infarction not treated with systemic thrombolysis (60.4 (14.3) pg/ml) than in patients with non-ischaemic chest pain (21.1 (4.3) pg/ml). Patients with ischaemic chest pain had intermediate values (39.3 (7.1) pg/ml). Patients with acute myocardial infarction treated with intravenous streptokinase had normal concentrations of plasma atrial natriuretic peptide (20.2 (3.6) pg/mg), which were significantly lower than those in patients with myocardial infarction not given streptokinase. These changes could not be explained by factors such as age, pre-existing hypertension, renal dysfunction, or cardiac failure, nor treatment other than streptokinase. Raised plasma concentrations of atrial natriuretic peptide in acute myocardial infarction may be a homoeostatic response acting to reduce atrial pressures by natriuresis, diuresis, and venodilatation. The lower concentrations of atrial natriuretic peptide in patients with acute myocardial infarction treated with streptokinase may reflect a short term beneficial haemodynamic effect of streptokinase.
UR - http://www.scopus.com/inward/record.url?scp=0024503544&partnerID=8YFLogxK
U2 - 10.1136/hrt.61.2.139
DO - 10.1136/hrt.61.2.139
M3 - Article
C2 - 2522310
AN - SCOPUS:0024503544
SN - 0007-0769
VL - 61
SP - 139
EP - 143
JO - BRITISH HEART JOURNAL
JF - BRITISH HEART JOURNAL
IS - 2
ER -
