TY - JOUR
T1 - Plasma neuropeptide Y concentration is increased after hemorrhage in conscious rats
T2 - Relative contributions of sympathetic nerves and the adrenal medulla
AU - Morris, Margaret
AU - Kapoor, Vimal
AU - Chalmers, John
PY - 1987/5
Y1 - 1987/5
N2 - Most peripheral noradrenergic nerves have been shown to contain the coexisting peptide, neuropeptide Y (NPY). The aim of this study was to determine whether NPY is released together with catecholamines during activation of the sympathoadrenal system by hemorrhagic stress in conscious rats. Plasma NPY rose from a baseline value of 7.7 ± 1.2 to 14.4 ± 2.7 and 14.9 ± 2.3 ng/ml (mean ± SEM, n = 8) 10 and 30 min after hemorrhage, respectively. Plasma norepinephrine (NE) and epinephrine concentrations rose immediately after hemorrhage and at 30 min were increased twofold and ninefold, respectively. To determine the source of the increase in circulating NPY after hemorrhage, rats were subjected to adrenalectomy or to chemical sympathectomy with intravenous (i.v.) 6-hydroxydopamine (6-OHDA). 6-OHDA-treated rats had no significant increase in plasma NPY after hemorrhage, whereas adrenalectomized rats had an enhanced NPY response to hemorrhage. These results suggest that the sympathetic nerves make the major contribution to the increase in plasma NPY concentrations after activation of the sympathoadrenal system by hemorrhagic stress.
AB - Most peripheral noradrenergic nerves have been shown to contain the coexisting peptide, neuropeptide Y (NPY). The aim of this study was to determine whether NPY is released together with catecholamines during activation of the sympathoadrenal system by hemorrhagic stress in conscious rats. Plasma NPY rose from a baseline value of 7.7 ± 1.2 to 14.4 ± 2.7 and 14.9 ± 2.3 ng/ml (mean ± SEM, n = 8) 10 and 30 min after hemorrhage, respectively. Plasma norepinephrine (NE) and epinephrine concentrations rose immediately after hemorrhage and at 30 min were increased twofold and ninefold, respectively. To determine the source of the increase in circulating NPY after hemorrhage, rats were subjected to adrenalectomy or to chemical sympathectomy with intravenous (i.v.) 6-hydroxydopamine (6-OHDA). 6-OHDA-treated rats had no significant increase in plasma NPY after hemorrhage, whereas adrenalectomized rats had an enhanced NPY response to hemorrhage. These results suggest that the sympathetic nerves make the major contribution to the increase in plasma NPY concentrations after activation of the sympathoadrenal system by hemorrhagic stress.
KW - 6-Hydroxydopamine
KW - Adrenalectomy
KW - Hemorrhage
KW - Plasma epinephrine
KW - Plasma neuropeptide Y
KW - Plasma norepinephrine
UR - http://www.scopus.com/inward/record.url?scp=0023212039&partnerID=8YFLogxK
U2 - 10.1097/00005344-198705000-00006
DO - 10.1097/00005344-198705000-00006
M3 - Article
C2 - 2439834
AN - SCOPUS:0023212039
VL - 9
SP - 541
EP - 545
JO - Journal of Cardiovascular Pharmacology
JF - Journal of Cardiovascular Pharmacology
SN - 0160-2446
IS - 5
ER -